Pharmacology, Toxicology and Environmental Health Commons^™

Phasic Activity Of Urinary Bladder Smooth Muscle In The Streptozotocin-Induced Diabetic Rat: Effect Of Potassium Channel Modulators, Bahareh Vahabi, Kim Lawson, Neil G. Mckay, Donna Sellers

Donna Sellers

Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+) channels are key regulators of bladder smooth muscle tone and thus may play a role in this altered phasic activity. In this study the effects of K+ channel modulators on the phasic activity of bladder strips from the streptozotocin-induced diabetic rat model of bladder dysfunction were investigated. Bladder strips from rats 1 week following streptozotocin administration and age-matched controls were mounted in tissue baths at 37 °C and the effects of K+ …