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Medicinal Chemistry and Pharmaceutics
Singlet oxygen generation; tunable fluorescent dyes; in-vitro protoporphyrin-ix; up-conversion; photosensitizing properties; efficient photosensitizers; photophysical properties; 5-aminolevulinic acid; clinical-applications
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Bodipy Dyes In Photodynamic Therapy, Kiew Lik Voon
Bodipy Dyes In Photodynamic Therapy, Kiew Lik Voon
Kiew Lik Voon
BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with O-3(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the …