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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Preparation, Evaluation And Metabolites Study In Rats Of Novel Isoginkgetin-Loaded Tpgs/Soluplus Mixed Nanomicelles, Xue Feng, Yu-Ting Chen, Lu-Ya Li, Yu-Peng Sun, Hai-Rong Wang, Lan-Tong Zhang
Preparation, Evaluation And Metabolites Study In Rats Of Novel Isoginkgetin-Loaded Tpgs/Soluplus Mixed Nanomicelles, Xue Feng, Yu-Ting Chen, Lu-Ya Li, Yu-Peng Sun, Hai-Rong Wang, Lan-Tong Zhang
Journal of Food and Drug Analysis
At present, cancer is one of the most lethal diseases in the world, and researchers are committed to developing effective anticancer drugs. Isoginkgetin (IGG) is a kind of biflavone with the potential to treat cancer due to the features of altering the cell cycle and inhibiting tumor cell infiltration. However, its solubility, absorbability and bioavailability are poor, so in this study, IGG was prepared into mixed nanomicelles and evaluated in vitro and in vivo. After condition optimization, IGG-loaded TPGS/soluplus mixed nanomicelles with particle size of 62.34 ± 1.10 nm, entrapment efficiency of 96.92 ± 0.66% and drug loading of 2.42 …