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Off-Target Based Drug Repurposing Using Systems Pharmacology, Brent M. Kuenzi
Off-Target Based Drug Repurposing Using Systems Pharmacology, Brent M. Kuenzi
USF Tampa Graduate Theses and Dissertations
The goal of this study was to identify novel drug repurposing opportunities in cancer by utilizing the off-target profiles of clinically relevant kinase inhibitors. This was based on the observation that the global target profiles of compounds are largely ignored and that many compounds have activity that cannot be explained by their cognate target alone. Additionally, by utilizing clinically relevant compounds, any results would hold a high potential for eventual clinical implementation. We utilized a systems pharmacology approach utilizing cell viability-based drug screening to identify compounds with beneficial off-target activity and then using chemical and phosphoproteomics in order to elucidate …