Other Life Sciences Commons^™

Quorum Sensing In Candida Albicans: Probing Farnesol’S Mode Of Action With 40 Natural And Synthetic Farnesol Analogs, Roman Shchepin, Jacob M. Hornby, Erin Burger, Timothy Niessen, Patrick H. Dussault, Kenneth Nickerson

Kenneth Nickerson Papers

The dimorphic fungus Candida albicans produces extracellular farnesol (3,7, 11-trimethyl-2,6,10-dodecatriene- 1-ol) which acts as a quorum-sensing molecule (QSM) to suppress filamentation. Of four possible geometric isomers of farnesol, only the E,E isomer possesses QSM activity. We tested 40 natural and synthetic analogs of farnesol for their activity in an N-acetylglucosamine-induced differentiation assay for germ tube formation (GTF). Modified structural features include the head group, chain length, presence or absence of the three double bonds, substitution of a backbone carbon by S, O, N, and Se heteroatoms, presence or absence of a 3-methyl branch, and the bulkiness of the hydrophobic …

Trends. Security, Stigma, And Biological Weapons, Ibpp Editor

International Bulletin of Political Psychology

This Trends article discusses the political psychology of security concerns pertaining to unclassified information relating to biological weapons and/or biosecurity and how it might be used to harm US security.

Phosphoproteomic Studies Of Smooth Muscle Contraction: Investigation Of Differential Phosphorylation In Relaxed/Contracted Rat Aortic Smooth Muscle Tissue Using Maldi-Tof Ms, Tonya M. Pekar

Theses, Dissertations and Capstones

Many human disorders are associated with the malfunction of smooth muscle tissue, or are related to the capabilities of its proper function—asthma, glaucoma, renal inefficiency, hypertension, and cardiovascular disease. Dysfunctional proteins are frequently implicated as the source of such disorders. As the second highest cause of death in the United States, the epidemic of cardiovascular disease makes the study of smooth muscle of utmost concern.

The capabilities of proteomics and mass spectrometry allow the entire proteome complement of a cell or tissue type to be analyzed at once. This investigation employs such techniques in an effort to better understand the …

An Ecological Study Of The Spotted Salamander, Ambystoma Maculatum, And Jefferson Salamander, A. Jeffersonianum, In West Virginia, Seth J. Myers

Theses, Dissertations and Capstones

The movements of Spotted Salamanders, Ambystoma maculatum, and Jefferson Salamanders, A. jeffersonianum, in and out of an ephemeral wetland in West Virginia were monitored for one breeding season using a drift fence lined with funnel traps. Significant movements of A. jeffersonianum coincided with rainfall and maximum daily air temperatures reaching a minimum of 5° C. Significant movements of A. maculatum coincided with rainfall and maximum daily air temperatures of at least 10° C. A. jeffersonianum preceded A. maculatum to the breeding site. Males of both species preceded females. The mark-recapture estimate of A. maculatum is 67 males and 25 females. …

Eight Gram-Negative Bacteria Are 10,000 Times More Sensitive To Cationic Detergents Than To Anionic Detergents, Soumitra Rajagopal, Nicole Eis, Kenneth Nickerson

Kenneth Nickerson Papers

In liquid culture, eight typical Gram-negative bacteria were ca. 10,000-fold more sensitive to cationic detergents than to the anionic detergent sodium dodecyl sulfate. Cetyltrimethylammonium bromide (CTAB) was inhibitory at concentrations ranging from 0.0006% to 0.01%. Four pseudomonads able to form biofilms were ca. 1000-fold more resistant to CTAB on Luria–Bertani agar plates than they were in liquid culture. A lasI mutant of Pseudomonas aeruginosa was only able to tolerate 0.1% CTAB on Luria–Bertani agar plates but could tolerate 5% CTAB when supplemented with homoserine lactone containing culture supernatants.

En culture liquide, huit bactéries Gram négatif typiques étaient ca. 10,000 fois …

Notes On Eryx, Omega, And Ata, Victor Fet

Biological Sciences Faculty Research

Observations on several Nabokov’s works (Pale Fire, Lolita) where geographic or zoological names provide sources for puns and hidden parallels.