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Unsaturated Fatty Acids Repress The Expression Of Atp-Binding Cassette Transporter A1 In Hepg2 And Fhs 74 Int Cells, Chai Siah Ku, Heather E. Rasmussen, Young-Ki Park, Elliot D. Jesch, Ji-Young Lee

Department of Nutrition and Health Sciences: Faculty Publications

Adenosine triphosphate–binding cassette transporter A1 (ABCA1) plays a critical role in the formation and metabolism of high-density lipoproteins (HDLs). Adenosine triphosphate–binding cassette transporter A1 in the liver and small intestine, in particular, accounts for approximately 90% of plasma HDL cholesterol. Therefore, any alterations in the hepatic and intestinal expression of ABCA1 could have a large impact on HDL biogenesis. We tested the hypothesis that ABCA1 expression is regulated differentially by different types of fatty acids in the liver and small intestine. Human hepatoma HepG2 and human small intestine epithelial FHs 74 Int cells were used as an in vitro model. …