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Articles 1 - 4 of 4
Full-Text Articles in Molecular, Genetic, and Biochemical Nutrition
Delta Tocotrienol Attenuates Nlrp3 Inflammasome Activation Via Inhibition Of Nf-Κb Priming And Reactive Oxygen Species Generation, Teresa Buckner
Delta Tocotrienol Attenuates Nlrp3 Inflammasome Activation Via Inhibition Of Nf-Κb Priming And Reactive Oxygen Species Generation, Teresa Buckner
College of Education and Human Sciences: Dissertations, Theses, and Student Research
Chronic, low-grade inflammation during obesity is associated with the development of metabolic dysfunction. The NLRP3 inflammasome is assembled in response to cellular stressors and leads to cytotoxic cytokines IL-1β and IL-18 production, which implicates the NLRP3 inflammasome in inflammatory conditions, including type 2 diabetes. Tocotrienols are antioxidant and anti-inflammatory forms of vitamin E. Delta-tocotrienol (dT3) displays NF-κB inhibitory and anti-oxidant abilities, and is easily isolated from the Annatto plant. My primary aim was to determine whether dT3 inhibits NLRP3 inflammasome activation and to compare the extent to which dT3 inhibits NLRP3 inflammasome with other tocotrienol forms, i.e. alpha-tocotrienol (aT3) and …
Chemopreventive Effects Of Polymethoxyflavones, Xian Wu
Chemopreventive Effects Of Polymethoxyflavones, Xian Wu
Doctoral Dissertations
Colon cancer is one of the major global public health issues, which severely threatens human health. Polymethoxyflavones (PMFs), a unique class of flavonoids, are abundantly and almost exclusively found in the peel of sweet oranges (Citrus sinensis) and mandarin oranges (Citrus reticulata). Nobiletin (NBT) is a major citrus flavonoid that has shown various health benefits, including anti-inflammation and anti-carcinogenesis. To better understand the chemopreventive effects of NBT, we systematically investigated the inhibitory effects of dietary NBT on colitis-associated colon carcinogenesis in azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice. We found that oral administration of NBT effectively decreased …
Genotoxic Effects Of Magnesium Deficiency In The Cardiovascular System And Their Relationships To Cardiovascular Diseases And Atherogenesis, Burton M. Altura, Nilank C. Shah, Gatha J. Shah, Bella T. Altura
Genotoxic Effects Of Magnesium Deficiency In The Cardiovascular System And Their Relationships To Cardiovascular Diseases And Atherogenesis, Burton M. Altura, Nilank C. Shah, Gatha J. Shah, Bella T. Altura
The School of Health Sciences Publications and Research
The authors present evidence for a novel, new hypothesis whereby magnesium deficiency (MgD) acts as a genotoxic agent which probably causes numerous, hertofore, unrecognized consequences, even over a short-term, on the physiological, molecular and biochemical machinery of cardiovascular tissues and cells. The end result of these genotoxic effects of MgD probably plays important roles in the etiology and generation of diverse cardiovascular diseases, atherosclerosis, inflammation, and strokes via alterations in the epigenome of cardiovascular tissues and cells. The importance of adequate water-borne and dietary levels of Mg is emphasized.
Suppression Of Nlrp3 Inflammasome By Γ-Tocotrienol Ameliorates Type 2 Diabetes, Yongeun Kim, Wei Wang, Meshail Okla, Inhae Kang, Regis Moreau, Soonkyu Chung
Suppression Of Nlrp3 Inflammasome By Γ-Tocotrienol Ameliorates Type 2 Diabetes, Yongeun Kim, Wei Wang, Meshail Okla, Inhae Kang, Regis Moreau, Soonkyu Chung
Department of Nutrition and Health Sciences: Faculty Publications
The Nod-like receptor 3 (NLRP3) inflammasome is an intracellular sensor that sets off the innate immune system in response to microbial-derived and endogenous metabolic danger signals. We previously reported that γ-tocotrienol (γT3) attenuated adipose tissue inflammation and insulin resistance in diet-induced obesity, but the underlying mechanism remained elusive. Here, we investigated the effects of γT3 on NLRP3 inflammasome activation and attendant consequences on type 2 diabetes. γT3 repressed inflammasome activation, caspase-1 cleavage, and interleukin (IL) 1β secretion in murine macrophages, implicating the inhibition of NLRP3 inflammasome in the anti-inflammatory and antipyroptotic properties of γT3. Furthermore, supplementation of leptin-receptor KO mice …