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Molecular, Genetic, and Biochemical Nutrition Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Molecular, Genetic, and Biochemical Nutrition
Retinoic Acid, Insulin, And Cycloheximide Alter Glycogen Homeostasis In Differentiating L6 Myoblasts, Aaron Armstrong
Retinoic Acid, Insulin, And Cycloheximide Alter Glycogen Homeostasis In Differentiating L6 Myoblasts, Aaron Armstrong
Doctoral Dissertations
Glycogen synthesis in skeletal muscle (SM) is responsible for the majority of post-prandial glucose disposal in healthy individuals. In type 2 diabetes mellitus (T2DM), compromised skeletal muscle glycogen synthesis contributes to hyperglycemia. L6 rat SM cells can develop insulin resistance with prolonged insulin stimulation and provide an in vitro model for mechanistic dysfunction in glycogen homeostasis. SM glycogen is synthesized by glycogen synthase (GS) in response to insulin stimulation. Canonically, insulin signaling increases GS activity through inhibition of its Ser641 regulator glycogen synthase kinase-3β (GSK3β) by protein kinase B (AKT). Proximal insulin signaling activates AKT via Ser473 phosphorylation which proceeds …
The Effects Of Retinoic Acid And Insulin On Glycogenesis In Hl1c Hepatoma Cells, Addison J. Bond, Guoxun Chen Dr.
The Effects Of Retinoic Acid And Insulin On Glycogenesis In Hl1c Hepatoma Cells, Addison J. Bond, Guoxun Chen Dr.
Chancellor’s Honors Program Projects
No abstract provided.
Role Of Vitamin A Status And Its Catabolism In The Regulation Of Glucose And Lipid Homeostasis In Rats Under Physiological And Disease Conditions, Yang Li
Doctoral Dissertations
The increased number of individuals with metabolic diseases has become a public health concern. Vitamin A (VA, retinol) is required to maintain the general health of an individual. How VA contributes to the regulation of glucose and lipid homeostasis in normal and metabolic disease states is unclear. VA’s physiological activities are mainly mediated by its metabolite, retinoic acid (RA), which activates several transcriptional factors in the nuclear receptor super family and in turn, regulates the expression of numerous genes for macronutrient metabolism. For the RA production, retinol is first oxidized into retinal and then from retinal to RA. We hypothesize …