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Molecular, Genetic, and Biochemical Nutrition Commons™
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Articles 1 - 4 of 4
Full-Text Articles in Molecular, Genetic, and Biochemical Nutrition
Retinoic Acid, Insulin, And Cycloheximide Alter Glycogen Homeostasis In Differentiating L6 Myoblasts, Aaron Armstrong
Retinoic Acid, Insulin, And Cycloheximide Alter Glycogen Homeostasis In Differentiating L6 Myoblasts, Aaron Armstrong
Doctoral Dissertations
Glycogen synthesis in skeletal muscle (SM) is responsible for the majority of post-prandial glucose disposal in healthy individuals. In type 2 diabetes mellitus (T2DM), compromised skeletal muscle glycogen synthesis contributes to hyperglycemia. L6 rat SM cells can develop insulin resistance with prolonged insulin stimulation and provide an in vitro model for mechanistic dysfunction in glycogen homeostasis. SM glycogen is synthesized by glycogen synthase (GS) in response to insulin stimulation. Canonically, insulin signaling increases GS activity through inhibition of its Ser641 regulator glycogen synthase kinase-3β (GSK3β) by protein kinase B (AKT). Proximal insulin signaling activates AKT via Ser473 phosphorylation which proceeds …
The Effects Of Retinoic Acid And Insulin On Glycogenesis In Hl1c Hepatoma Cells, Addison J. Bond, Guoxun Chen Dr.
The Effects Of Retinoic Acid And Insulin On Glycogenesis In Hl1c Hepatoma Cells, Addison J. Bond, Guoxun Chen Dr.
Chancellor’s Honors Program Projects
No abstract provided.
Long-Term Treatment With Insulin And Retinoic Acid Increased Glucose Usage In L6 Muscle Cells Via Glycogenesis, Matthew Ray Goff
Long-Term Treatment With Insulin And Retinoic Acid Increased Glucose Usage In L6 Muscle Cells Via Glycogenesis, Matthew Ray Goff
Doctoral Dissertations
Skeletal muscle glucose metabolism can affect whole body glucose homeostasis significantly. Vitamin A (VA) plays a role in a number of physiological functions including glucose metabolism. However, its role in skeletal muscle glucose metabolism has not been well established. Insulin controls glucose metabolism in the skeletal muscle via the regulations of glucose uptake, glycogenesis, and glycolysis. We hypothesize that insulin and VA signaling pathways may converge to regulate glucose metabolism in skeletal muscle. Here, the effects of retinoic acid (RA) alone and in combination with insulin on glucose utilization in rat L6 muscle cells were studied. L6 cells were treated …
Effects Of Grain Sorghum Muffin On Blood Glucose And Insulin Responses In Prediabetic Men, Xuan Gu
Effects Of Grain Sorghum Muffin On Blood Glucose And Insulin Responses In Prediabetic Men, Xuan Gu
Graduate Theses and Dissertations
Prediabetes is a sub-health condition in the development to type 2 diabetes, which has been long overlooked. Grain sorghum contains functional starch fractions, which have been widely reported for their potential on blood glucose control and diabetes prevention. A human study with prediabetic men was conducted to investigate the effects of sorghum starch on postprandial blood glucose and insulin levels. Grain sorghum and wheat (control) muffins containing 50 g total starch were consumed by 15 prediabetic male subjects on two mornings with a 1-week washout period. Plasma samples were collected on -15 (baseline), 0, 15, 30, 45, 60, 75, 90, …