Molecular, Genetic, and Biochemical Nutrition Commons^™

The Prevention Of Obesity-Associated Colorectal Cancer Via Dietary Suppression Of Inflammation-Driven Wnt-Signaling, Jinchao Li

Doctoral Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer deaths in the United States. A number of population studies have established that modifiable lifestyle factors such as obesity plays an important role in colorectal carcinogenesis. In the United States, more than one-third of adults are obese and obesity prevalence rates have no sign of decrease. Therefore, the development of effective strategies to prevent obesity-induced CRC is a public health priority. This study aimed to investigate whether genetic or dietary strategies can prevent obesity-induced CRC and determine the potential molecular mechanisms underlying the prevention effects of these strategies. We used …