Molecular, Genetic, and Biochemical Nutrition Commons^™

Zhx2 Regulation Of Lipid Metabolism And The Balance Between Cardiovascular And Hepatic Health, Kate Townsend Creasy

Theses and Dissertations--Pharmacology and Nutritional Sciences

The growing obesity epidemic in America carries with it numerous health risks, including diabetes, increased serum lipid levels, and excess fat accumulation in the liver. If these conditions persist or become exacerbated, they may lead to the development of cardiovascular disease, the current leading cause of death among Americans, or to nonalcoholic fatty liver disease (NAFLD) which can progress to hepatocellular carcinoma (HCC), one of the deadliest forms of cancer. Better understanding of the genes involved in these diseases can lead to improved identification of at-risk individuals and treatment strategies.

Our lab previously identified zinc fingers and homeoboxes 2 (Zhx2) …