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Molecular, Genetic, and Biochemical Nutrition Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Molecular, Genetic, and Biochemical Nutrition
Calcium And Leucine Modulation Of Airway Inflammation, Patricia Louise Brown
Calcium And Leucine Modulation Of Airway Inflammation, Patricia Louise Brown
Doctoral Dissertations
Over the past several decades the prevalence of obesity and asthma have increased in a parallel fashion. Recent studies reported a positive relationship between the two disorders that may in fact be causal. Although the link between obesity and asthma has become widely recognized, the underlying pathophysiological connection is not elucidated. Increased markers of inflammatory and oxidative stress are present in obesity and asthma suggesting the link is immunological. The systemic inflammation observed in obesity may potentially initiate adverse affects in the airways. Previous studies have shown that consumption of dairy foods (rich in calcium and leucine) suppress 1,25-dihydroxycholecalciferol (calcitriol) …
Role Of Leucine In Modulation Of Mitochondrial Biogenesis And Sirt1-Ampk Signaling In C2c12 Myotubes, Chunzi Liang
Role Of Leucine In Modulation Of Mitochondrial Biogenesis And Sirt1-Ampk Signaling In C2c12 Myotubes, Chunzi Liang
Doctoral Dissertations
Mitochondrial dysfunction in skeletal muscle has been considered as a crucial step in the development of metabolic diseases, including insulin resistance syndrome, type 2 diabetes and cardiovascular diseases. Previous studies have demonstrated that dietary branched-chain amino acids, particularly leucine, protects against high-fat diet induced impairment of mitochondria and insulin resistance in skeletal muscle and adipose tissue through mTOR-dependent and independent pathways. In addition, previous ex vivo and in vitro approaches from this laboratory indicate that leucine and its metabolites (HMB and KIC) stimulate mitochondrial biogenesis and promote energy partitioning from adipocytes to muscle cells, partially through SIRT1 signaling. Moreover, recent …
The Effects Of Leucine And Dairy Products On Adipose Tissue Inflammation: The Role Of Adipocyte Derived Microvesicles, Benjamin Jones Curry
The Effects Of Leucine And Dairy Products On Adipose Tissue Inflammation: The Role Of Adipocyte Derived Microvesicles, Benjamin Jones Curry
Doctoral Dissertations
Obesity is characterized by chronic oxidative and inflammatory stress, and adipose tissue is a significant source of inflammatory cytokines. Previous studies demonstrated that dairy products (rich in calcium and leucine) can alleviate obesity-associated inflammatory stress through suppression of 1, 25-dihydroxycholecalciferol (calcitriol) with calcium and the high leucine content in dairy. We have also shown leucine treatment increases anti-inflammatory adiponectin expression and decreases pro-inflammatory cytokines TNF-a [alpha], MCP-1, and IL-6 expression in adipocytes. Therefore, we sought to determine if these alterations in inflammatory cytokine production could have a functional effect on the inflammatory process, specifically monocyte – endothelial cell adhesion as …