Molecular, Genetic, and Biochemical Nutrition Commons^™

Low Energy Availability With And Without A High-Protein Diet Suppresses Bone Formation And Increases Bone Resorption In Men: A Randomized Controlled Pilot Study, Chaise Murphy, Laura D. Bilek, Karsten Koehler

Department of Nutrition and Health Sciences: Faculty Publications

Suppression of insulin-like growth factor 1 (IGF-1) and leptin secondary to low energy availability (LEA) may contribute to adverse effects on bone health. Whether a high-protein diet attenuates these effects has not been tested. Seven men completed three five-day conditions operationally defined as LEA (15 kcal kg fat-free mass (FFM)^-1 day^-1) with low protein (LEA-LP; 0.8 g protein·kg body weight (BW)^-1), LEA with high protein (LEA-HP; 1.7 g protein·kg BW^-1) and control (CON; 40 kcal·kg FFM^-1·day^-1, 1.7 g protein·kg BW^-1). In all conditions, participants expended 15 kcal·kg …