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Full-Text Articles in Molecular, Genetic, and Biochemical Nutrition
Transcription Factor 7-Like 2 (Tcf7l2) Gene Polymorphisms In Relation To The Risk Of Type 2 Diabetes In Three Ethnicities, Ling Xu
FIU Electronic Theses and Dissertations
Type 2 Diabetes (T2D) disproportionally affects ethnic minorities in the United States. The development of T2D involves complex interaction between environmental factors and genetic predisposition. The genetic associations of six single nucleotide polymorphisms (SNPs) in TCF7L2 gene with the risk of T2D were evaluated in three high risk minority populations: Cuban Americans, Haitian Americans, and African Americans. For Cuban Americans, four SNPs (rs7901695, rs4506565, rs7903146 and rs11225537) were significantly associated with the risk of T2D after multivariable adjustment (p=0.018, p=0.016, p=0.014, and p=0.0008, respectively). Among controls, risk allele carriers of SNPs rs7901695, rs4506565 and rs7903146 had significantly higher fasting glucose …