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Molecular, Genetic, and Biochemical Nutrition Commons™

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Series

2012

Articles 1 - 9 of 9

Full-Text Articles in Molecular, Genetic, and Biochemical Nutrition

Eating Behaviors Of Older Adults Participating In Government-Sponsored Programs With Different Demographic Backgrounds, Yeon Bai, Shahla M. Wunderlich, Joseph Brusca, Johnson-Austin Marti, Michelle O'Malley Oct 2012

Eating Behaviors Of Older Adults Participating In Government-Sponsored Programs With Different Demographic Backgrounds, Yeon Bai, Shahla M. Wunderlich, Joseph Brusca, Johnson-Austin Marti, Michelle O'Malley

Department of Nutrition and Food Studies Scholarship and Creative Works

The purpose of this study was to determine the food behaviors of nutritionally high-risk seniors as a function of their racial background, gender, marital status, and education level. A total of 69 seniors were identified to be at high nutritional risk using the Nutrition Screening Initiative (NSI) checklist. A supplemental questionnaire (SQ) was created to examine the risk factors in relation to the participant’s demographic background. Key results indicated that Asians practiced healthy food behaviors and women were more likely to eat alone (p≤0.05). Married participants (90.9%) were most likely to consume 2 meals or more each day. College educated …

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Medical Nutrition Therapy Provided To Adult Hematopoietic Stem Cell Transplantation Patients, Mary G. Habschmidt, Cheryl A. Bacon, Mary B. Gregoire, Heather E. Rasmussen Oct 2012

Medical Nutrition Therapy Provided To Adult Hematopoietic Stem Cell Transplantation Patients, Mary G. Habschmidt, Cheryl A. Bacon, Mary B. Gregoire, Heather E. Rasmussen

Department of Nutrition and Health Sciences: Faculty Publications

This study explored the current medical nutrition therapy (MNT) provided to adult patients undergoing hematopoietic stem cell transplantation (HSCT) and examined the current and desired role of registered dietitians (RDs) in providing MNT. A total of 60 RDs (57% response rate) responded to an electronic questionnaire. Descriptive statistics and χ2 analyses (SPSS, version 18) were used. Results revealed the primary form of diet was oral, and for patients on nutrition support, parenteral nutrition (PN) was used more frequently (16%–31%) than enteral nutrition (EN) (5%–9%; P ≤ .05). Nutrition support decisions were based on patients’ individualized needs rather than established …

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Successful Aging: A Psychosocial Resources Model For Very Old Adults, G. Kevin Randall, Peter Martin, Mary Ann Johnson, Leonard W. Poon Jan 2012

Successful Aging: A Psychosocial Resources Model For Very Old Adults, G. Kevin Randall, Peter Martin, Mary Ann Johnson, Leonard W. Poon

Department of Nutrition and Health Sciences: Faculty Publications

Objectives.Using data from the first two phases of the Georgia Centenarian Study, we proposed a latent factor structure for the Duke OARS domains: Economic Resources, Mental Health, Activities of Daily Living, Physical Health, and Social Resources. Methods. Exploratory and confirmatory factor analyses were conducted on two waves of the Georgia Centenarian Study to test a latent variable measurement model of the five resources; nested model testing was employed to assess the final measurement model for equivalency of factor structure over time. Results. The specified measurement model fit the data well at Time 1. However, at Time 2, …

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Regulation Of Expression Of Citrate Synthase By The Retinoic Acid Receptor-Related Orphan Receptor A (Rorα), Christine Crumbley, Yongjun Wang, Subhashis Banerjee, Thomas P. Burris Jan 2012

Regulation Of Expression Of Citrate Synthase By The Retinoic Acid Receptor-Related Orphan Receptor A (Rorα), Christine Crumbley, Yongjun Wang, Subhashis Banerjee, Thomas P. Burris

Department of Nutrition and Health Sciences: Faculty Publications

The retinoic acid receptor-related orphan receptor α (RORα) is a member of the nuclear receptor superfamily of transcription factors that plays an important role in regulation of the circadian rhythm and metabolism. Mice lacking a functional RORα display a range of metabolic abnormalities including decreased serum cholesterol and plasma triglycerides. Citrate synthase (CS) is a key enzyme of the citric acid cycle that provides energy for cellular function. Additionally, CS plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis. Here, we identified a functional RORα response element (RORE) in the promoter of the CS gene. ChIP …

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Regulation Of P53 Stability And Apoptosis By A Ror Agonist, Yongjun Wang, Laura A. Solt, Douglas J. Kojetin, Thomas P. Burris Jan 2012

Regulation Of P53 Stability And Apoptosis By A Ror Agonist, Yongjun Wang, Laura A. Solt, Douglas J. Kojetin, Thomas P. Burris

Department of Nutrition and Health Sciences: Faculty Publications

Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anticancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORa. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

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Evolution Of Starvation Resistance In Drosophila Melanogaster: Measurement Of Direct And Correlated Responses To Artificial Selection, Tiffany E. Schwasinger-Schmidt, Stephen D. Kachman, Lawrence G. Harshman Jan 2012

Evolution Of Starvation Resistance In Drosophila Melanogaster: Measurement Of Direct And Correlated Responses To Artificial Selection, Tiffany E. Schwasinger-Schmidt, Stephen D. Kachman, Lawrence G. Harshman

Lawrence G. Harshman Publications

Laboratory selection for resistance to starvation has been conducted under relatively controlled conditions to investigate direct and correlated responses to artificial selection. With regard to starvation resistance, there are three physiological routes by which the trait can evolve: resource accumulation, energy conservation and starvation tolerance. A majority of energetic compounds and macromolecules including triglycerides, trehalose and other sugars, and soluble protein increased in abundance as a result of selection. Movement was additionally investigated with selected males moving less than control males and selected females exhibiting a similar response to selection. Results obtained from this study supported two of the possible …

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Cgi-58/Abhd5-Derived Signaling Lipids Regulate Systemic Inflammation And Insulin Action, Caleb C. Lord, Jenna L. Betters, Pavlina T. Ivanova, Stephen B. Milne, David S. Myers, Jennifer Madenspacher, Gwynneth Thomas, Soonkyu Chung, Mingxia Liu, Matthew A. Davis, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, John S. Parks, Dawn L. Brasaemle, Michael B. Fessler, H. Alex Brown, J. Mark Brown Jan 2012

Cgi-58/Abhd5-Derived Signaling Lipids Regulate Systemic Inflammation And Insulin Action, Caleb C. Lord, Jenna L. Betters, Pavlina T. Ivanova, Stephen B. Milne, David S. Myers, Jennifer Madenspacher, Gwynneth Thomas, Soonkyu Chung, Mingxia Liu, Matthew A. Davis, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, John S. Parks, Dawn L. Brasaemle, Michael B. Fessler, H. Alex Brown, J. Mark Brown

Department of Nutrition and Health Sciences: Faculty Publications

Mutations of comparative gene identification 58 (CGI-58) in humans cause Chanarin-Dorfman syndrome, a rare autosomal recessive disease in which excess triacylglycerol (TAG) accumulates in multiple tissues. CGI-58 recently has been ascribed two distinct biochemical activities, including coactivation of adipose triglyceride lipase and acylation of lysophosphatidic acid (LPA). It is noteworthy that both the substrate (LPA) and the product (phosphatidic acid) of the LPA acyltransferase reaction are wellknown signaling lipids. Therefore, we hypothesized that CGI-58 is involved in generating lipid mediators that regulate TAG metabolism and insulin sensitivity. Here, we show that CGI-58 is required for the generation of signaling lipids …

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Effects Of Glycerol And Creatine Hyperhydration On Doping-Relevant Blood Parameters, Thelma P. Polyviou, Chris Easton, Lukas Beis, Dalia Malkova, Pantazis Takas, Cathertine Hambly, John R. Speakman, Karsten Koehler, Yannis P. Pitsiladis Jan 2012

Effects Of Glycerol And Creatine Hyperhydration On Doping-Relevant Blood Parameters, Thelma P. Polyviou, Chris Easton, Lukas Beis, Dalia Malkova, Pantazis Takas, Cathertine Hambly, John R. Speakman, Karsten Koehler, Yannis P. Pitsiladis

Department of Nutrition and Health Sciences: Faculty Publications

Glycerol is prohibited as an ergogenic aid by the World Anti-Doping Agency (WADA) due to the potential for its plasma expansion properties to have masking effects. However, the scientific basis of the inclusion of Gly as a “masking agent” remains inconclusive. The purpose of this study was to determine the effects of a hyperhydrating supplement containing Gly on doping-relevant blood parameters. Nine trained males ingested a hyperhydrating mixture twice per day for 7 days containing 1.0 g·kg−1 body mass (BM) of Gly, 10.0 g of creatine and 75.0 g of glucose. Blood samples were collected and total hemoglobin (Hb) …

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Muscadine Grape (Vitis Rotundifolia) And Wine Phytochemicals Prevented Obesity-Associated Metabolic Complications In C57bl/6j Mice, Vishnupriya Gourineni, Neil F. Shay, Soonkyu Chung, Amandeep K. Sandhu, Liwei Gu Jan 2012

Muscadine Grape (Vitis Rotundifolia) And Wine Phytochemicals Prevented Obesity-Associated Metabolic Complications In C57bl/6j Mice, Vishnupriya Gourineni, Neil F. Shay, Soonkyu Chung, Amandeep K. Sandhu, Liwei Gu

Department of Nutrition and Health Sciences: Faculty Publications

The objective of this study was to determine the effects of muscadine grape or wine (cv. Noble) phytochemicals on obesity and associated metabolic complications. Muscadine grape or wine phytochemicals were extracted using Amberlite FPX66 resin. Male C57BL/6J mice were given a low-fat diet (LF, 10% kcal fat), high-fat diet (HF, 60% kcal fat), HF + 0.4% muscadine grape phytochemicals (HF+MGP), or HF + 0.4% muscadine wine phytochemicals (HF+MWP) for 15 weeks. At 7 weeks, mice fed HF+MGP had significantly decreased body weights by 12% compared to HF controls. Dietary MGP or MWP supplementation reduced plasma content of free fatty acids, …

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