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Full-Text Articles in Molecular, Genetic, and Biochemical Nutrition
Novel Role Of Intestinal Lipid Transport In Food Allergy And Cholesterol Homeostasis, Jianing Li
Novel Role Of Intestinal Lipid Transport In Food Allergy And Cholesterol Homeostasis, Jianing Li
Theses and Dissertations--Pharmacology and Nutritional Sciences
The small intestine is the main organ for food digestion and nutrient absorption. It is constantly exposed to antigen and immunomodulatory agents from diet and commensal microbiota. Thus, the intestine is the largest compartment of the immune system in the body. Peanuts and many other allergen resources contain triglycerides, which may affect the antigen absorption through the intestine, but their effects on sensitization and anaphylaxis are unknown. We found that medium chain triglycerides (MCT) promoted antigen absorption into Peyer’s Patches, rather than into the blood directly. Both gavage and feeding of MCT plus peanut protein induced spontaneous allergic sensitization. MCT-sensitized …