Molecular, Genetic, and Biochemical Nutrition Commons^™

Effects Of Histone Deacetylase Inhibitors On Vitamin D Activity In Human Breast Cancer Cells, Brooke Savage

Masters Theses 1911 - February 2014

Breast cancer is one of the leading causes of death in women cancer cases worldwide. Cancer is the result of environmental and genetic factors that contribute to alterations in cellular control, proliferation, differentiation and apoptosis. Vitamin D is emerging as an important nutrient in the prevention and treatment of cancer due to its ability to modulate proliferation and apoptosis in vivo and in vitro. To accomplish this, Vitamin D exerts its biological activity by binding to a specific, high-affinity intracellular vitamin D receptor (VDR). VDR expression is identified in mammary cancer cell lines, but levels are reduced compared to …