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Molecular, Genetic, and Biochemical Nutrition Commons™
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Articles 1 - 2 of 2
Full-Text Articles in Molecular, Genetic, and Biochemical Nutrition
The Role Of Sr-B1 In Lipid Metabolism And Inflammation In 3t3-L1 Adipocytes, Christina Jiang
The Role Of Sr-B1 In Lipid Metabolism And Inflammation In 3t3-L1 Adipocytes, Christina Jiang
University Scholar Projects
Obesity is associated with a number of complications that may increase the risk for chronic disease, including inflammation and dysfunctional high-density lipoprotein (HDL) particles. Scavenger receptor class B member 1 (SR-B1) is an HDL receptor found in the cell plasma membrane involved in cholesterol exchange and the initiation of intracellular signaling cascades. During the process of adipocyte (fat cell) formation (adipogenesis), there is a delicate balance of transcriptional programs that affect cholesterol transport and facilitate lipid accumulation. Mice fed a high fat diet have increased SR-B1 mRNA expression in adipose tissue depots. Furthermore, SR-B1 mRNA expression was significantly increased in …
The Effect Of Polyphenol-Rich Black Currant Extract On Lipogenic And Inflammatory Gene Expression In Diet Induced Obesity Mice, Ellen Harness
The Effect Of Polyphenol-Rich Black Currant Extract On Lipogenic And Inflammatory Gene Expression In Diet Induced Obesity Mice, Ellen Harness
Honors Scholar Theses
Hyperlipidemia and hyperglycemia frequently occur in obese population. As chronic, low-grade inflammation is closely associated with obesity, we investigated if polyphenol-rich blackcurrant extract (BCE) can prevent inflammation and diet-induced metabolic disturbances in mice. Male C57BL/6J mice were given a modified AIN-93M control diet containing high fat/high cholesterol (16% fat, 0.25% cholesterol by weight) or the same diet supplemented with 0.1% BCE (wt/wt) for 12 weeks. No significant differences in total body weight or liver weight occurred between the two groups. BCE-fed mice had fewer crown-like structures (CLS) with concomitant decreases in mRNA abundance of F4/80, CD68, and inhibitor of nuclear …