Molecular, Genetic, and Biochemical Nutrition Commons^™

Physiological Importance Of 1,25(Oh)2D3 Membrane-Initiated And Nuclear Actions In Chickens As A Function Of Growth, And Maturation In Male And Female Chickens, Birgitta Larsson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

It is well established that l,25(OH)₂D₃ is a major regulator of calcium homeostasis. The steroid exerts its effects on its target organs by two mechanisms, a slow mechanism mediated by nuclear vitamin D receptors (nVDR), and a rapid mechanism mediated by the l,25(OH)₂D₃ membrane-associated rapid response steroid binding protein (l,25D₃-MARRS bp). In this dissertation, the physiological relevance of membrane initiated steroid signaling was investigated by studying the correlation of age in male and female chickens with the magnitude of responses to l,25(OH)₂D₃ in duodena from 7-, 14-, 28-, and …