Nutrition Commons^™

Perfluorooctanoic Acid (Pfoa) Or Perfluorooctane Sulfonate (Pfos) And Dna Methylation In Newborn Dried Blood Spots In The Upstate Kids Cohort, Sonia L Robinson, Xuehuo Zeng, Weihua Guan, Rajeshwari Sundaram, Pauline Mendola, Diane L Putnick, Robert A Waterland, Chathura J Gunasekara, Kurunthachalam Kannan, Chongjing Gao, Erin M Bell, Edwina H Yeung

Children’s Nutrition Research Center Staff Publications

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are persistent organic pollutants which may alter prenatal development, potentially through epigenetic modifications. Prior studies examining PFOS/PFOA and DNA methylation have relatively few subjects (n < 200) and inconsistent results. We examined relations of PFOA/PFOS with DNA methylation among 597 neonates in the Upstate KIDS cohort study. PFOA/PFOS were quantified in newborn dried blood spots (DBS) using high-performance liquid chromatography/tandem mass spectrometry. DNA methylation was measured using the Infinium MethylationEPIC BeadChip with DNA extracted from DBS. Robust linear regression was used to examine the associations of PFOA/PFOS with DNA methylation at individual CpG sites. Covariates included sample plate, estimated cell type, epigenetically derived ancestry, infant sex and plurality, indicators of maternal socioeconomic status, and prior pregnancy loss. In supplemental analysis, we restricted the analysis to 2242 CpG sites previously identified as Correlated Regions of Systemic Interindividual Variation (CoRSIVs) which include metastable epialleles. At FDR90th percentile was related to DNA methylation at cg15557840, near SCRT2, SRXN1; PFOS>90th percentile was related to 2 CpG sites in a sex-specific manner (cg19039925 in GVIN1 in boys and cg05754408 in ZNF26 in girls). When analysis was restricted to CoRSIVs, log-scaled, continuous PFOS concentration was related to DNA methylation at cg03278866 within PTBP1. In conclusion, there was limited evidence of an association between high concentrations of PFOA/PFOS and DNA methylation in newborn DBS in the Upstate KIDS cohort. These …

Implementation Fidelity Of Nutritional Counselling, Iron And Folic Acid Supplementation Guidelines And Associated Challenges In Rural Uasin Gishu County Kenya, Roselyter Riang’A, Anne Nangulu, Jacqueline Broerse

Population Health, East Africa

Background: Implementation fidelity which is defined as the degree to which programmes are implemented as intended is one of the factors that affect programme outcome, thus requiring careful examination. This study aims to acquire insight into the degree to which nutritional counselling and Iron and Folic Acid supplementation (IFAs) policy guidelines during pregnancy have been implemented as intended and the challenges to implementation fidelity.

Methods: Data were collected in rural Uasin Gishu County in the western part of Kenya through document analysis, questionnaires among intervention recipients (n = 188) and semi-structured interviews with programme implementers (n = 6). …

Healthy Pregnancies And Essential Fats: Focus Group Discussions With Zambian Women On Dietary Need And Acceptability Of A Novel Rusf Containing Fish Oil Dha, Catherine Chunda-Liyoka, Mwansa Ketty Lubeya, Mercy Imakando, Sophia Kisling, Sonoor Majid, Mary Willis, Charles Wood, Chipepo Kankasa, Concetta C. Dirusso

Department of Nutrition and Health Sciences: Faculty Publications

Background: Nut butter-based Ready to Use Supplemental Foods (RUSF) are an effective way to add nutrients and calories to diets of malnourished and food insecure populations. The RUSF formulations have been further modified to add micronutrients including iron and folic acid needed during pregnancy and lactation. Because docosahexaenoic acid (DHA, C22:6 n-3) enhances fetal development and birth outcomes, it has been suggested that perhaps RUSF formulations for pregnancy should also include this Omega 3 fatty acid. The goal of the present study was to gain an understanding of Zambian women’s knowledge of nutritional needs in pregnancy through structured focus group …

Nutrient And Food Group Intakes Of Low-Income Pregnant Women By Race/Ethnicity, Alla M. Hill, Danielle L. Nunnery Phd, Rdn, Ldn, Alice Ammerman Drph, Jigna M. Dharod Phd

Journal of Health Disparities Research and Practice

In an exploratory study, a convenience sample of 148 pregnant women was recruited from a WIC clinic in the southeast region of the U.S. to: 1) Examine and compare daily nutrient and food group intakes of WIC pregnant women to national guidelines, and; 2) Determine racial/ethnic differences in nutrient and food group intakes among WIC pregnant women. Women were selected for the study if they were: ≥ 18 y, in 2^nd trimester of pregnancy, and if they spoke English or Spanish as a first language. Upon recruitment, participants were interviewed to collect information on their socio-demographics, including race/ethnicity. Additionally, …

Simple Strategies For A Healthy Pregnancy, Une Applied Nutrition Program

All Student-Created Educational Resources

This handout gives the audience ideas for meeting the nutritional needs of teens for a healthy pregnancy. Tips for incorporating healthy foods and physical activity into a regular routine are included. The importance of nutrition during an adolescent pregnancy is briefly overviewed.

Prevent The Progression Of Gestational Diabetes After Pregnancy, Yasmin Barakat

All Student-Created Educational Resources

This handout informs the audience about ways to reduce the risk of or even prevent the progression of gestational diabetes into needing insulin medication or after pregnancy. This will include tips on healthy defaults for dietary and lifestyle modifications such as making healthy alternatives easy and more attractive, as well as the role of physical activity in diabetes prevention, and maintaining weight. It will also include information on nutrient needs while pregnant.

The Type Of Dietary Fat In An Isocaloric Breakfast Meal Does Not Modify Postprandial Metabolism In Overweight/Obese Pregnant Women, Mary Lesser, Kasuen Mauldin, Lisa Sawrey-Kubicek, Virginia Gildengorin, Janet King

Faculty Publications

Almonds provide a satiating, healthy source of fat and fiber. The postprandial metabolic and satiety response to 2 ounces of nuts or dairy was assessed in 18 overweight/obese women during late pregnancy. Serum glucose, triglycerides, insulin, c-peptide, leptin, ghrelin, and lipoprotein particles were measured prior to and during a 5-h postprandial period following the consumption of an isocaloric breakfast meal with equivalent amounts of fat from either nuts or dairy on two separate mornings. Satiety was assessed by visual analogue scale (VAS) questionnaires and ad libitum food intake at the end of the study. At 33 weeks gestation, the women …

Assessment Of Maternal And Infant Outcomes Of Moderately Malnourished Pregnant Adolescents In Malawi, Alyssa Marie Friebert

Master's Theses

Background: Adolescent childbearing and maternal malnutrition are common in low- and middle-income countries and are associated with increased risk for poor maternal and infant outcomes. Adolescent pregnancy compounded with moderate malnutrition exacerbates outcomes common to both individually. Supplementary foods may be a way to improve outcomes in malnourished adolescent pregnant women.

Objective: To retrospectively assess maternal and infant outcomes in moderately malnourished pregnant young adolescents (16-17 YO), older adolescents (18-19 YO), and adults (≥20 YO) in response to one of three nutritional interventions and in a pooled treatment group analysis, and to assess differences in infant outcomes by infant gender. …

The Effects Of Pre-Pregnancy Tobacco Use On Food Cravings And Weight Gain In Pregnancy, Lauren E. Blau

Legacy Theses & Dissertations (2009 - 2024)

Smoking cessation is associated with greater frequency of food cravings, even when controlling for body mass index. Recent studies have indicated similarities between obese women and women who smoke tobacco in mood states and food craving frequency. This is consistent with the common substrate hypothesis, which postulates that shared neural pathways mediate craving across multiple domains, and could explain why it is common for women attempting to quit smoking to gain weight. Smoking cessation prior to pregnancy is strongly encouraged due to the adverse effects of tobacco use on the developing fetus. Studies have shown that women who quit smoking …

Assessing The Effect Of Nutritional Interventions On Body Composition Changes During Pregnancy In Moderately Malnourished Malawian Women, Megan K. Kitagawa

Master's Theses

Background: Malnutrition can affect the body composition changes that occur in healthy pregnancy, resulting in adverse effects to both the mother and infant. Supplementary foods with high quality protein may result in more favorable changes in lean mass and fat mass in pregnant malnourished women.

Objective: To retrospectively assess changes in body composition in moderately malnourished pregnant Malawian women in response to one of three nutritional interventions.

Methods: Height, weight, MUAC, and TSF were measured in pregnant women with MUAC >20.6 cm and19) were compared using ANOVA. If differences were detected, differences between groups were tested using the Tukey HSD …

Maternal Choline Supplementation Alters Fetal Growth Patterns In A Mouse Model Of Placental Insufficiency, Julia H. King, Sze Ting (Cecilia) Kwan, Jian Yan, Kevin C. Klatt, Xinyin Jiang, Mark S. Roberson, Marie A. Caudill

Publications and Research

Impairments in placental development can adversely affect pregnancy outcomes. The bioactive nutrient choline may mitigate some of these impairments, as suggested by data in humans, animals, and human trophoblasts. Herein, we investigated the effects of maternal choline supplementation (MCS) on parameters of fetal growth in a Dlx3+/− (distal-less homeobox 3) mouse model of placental insufficiency. Dlx3+/− female mice were assigned to 1X (control), 2X, or 4X choline intake levels during gestation. Dams were sacrificed at embryonic days E10.5, 12.5, 15.5, and 18.5. At E10.5, placental weight, embryo weight, and placental efficiency were higher in 4X versus 1X choline. Higher concentrations …

Risk Factors Of Premature Rupture Of Membrane, Maryuni Maryuni, Dedeh Kurniasih

Kesmas

Angka kematian ibu di Indonesia berdasarkan Survei Demografi dan Kesehatan Indonesia (SDKI) tahun 2012 sebanyak 359 per 100.000 kelahiran hidup. Penyebab kematian ibu tersebut masih didominasi oleh pendarahan, pre-eklampsia/eklampsia, dan infeksi. Salah satu penyebab infeksi adalah ketuban pecah dini (KPD). KPD dapat meningkatkan morbiditas dan mortalitas pada ibu dan anak. Insiden kejadian KPD sekitar 10,7% dari seluruh persalinan. Penelitian ini bertujuan untuk mengetahui faktor risiko kejadian KPD di Rumah Sakit Ibu dan Anak (RSIA) ANNISA Citeureup, Kabupaten Bogor tahun 2014. Penelitian ini merupakan penelitian analitik dengan rancangan penelitian kasus kontrol. Sampel terdiri dari 114 orang kasus ibu yang mengalami KPD …

The Effects Of Iron Deficiency Anemia And Iron Supplementation In Pregnancy, Anna J. Cox

Senior Honors Theses

Iron deficiency anemia (IDA) is a condition that occurs in both underdeveloped and developed countries worldwide. This disorder is diagnosed in an individual who presents the common signs and symptoms of anemia along with consistently low clinical markers of stored iron. Iron deficiency (ID) usually precedes a diagnosis of IDA as the insufficient amount of iron often goes undetected until one’s quality of life is diminished. Certain populations, such as women who are pregnant or of reproductive age, are particularly at risk for ID and the development of IDA. During pregnancy, the recommended dietary allowance (RDA) for iron is greater …

Maternal Obesity And Incidence Of Depression, Caroline A. Habjan

Renée Crown University Honors Thesis Projects - All

Obesity is a national epidemic in the United States, which both directly and indirectly affects the social productivity of individuals, the American macro economy and individuals’ personal health and well being. Depression often interferes with an individual’s ability to work, sleep, study, eat, and enjoy life. A maternal state of both obesity and depression may cause serious adverse medical conditions in the mother’s child. Taking steps to treat depression and obesity are critical in the construct of modern medicine. This project yields results that have the potential to make treatment options better tailored, more efficient, effective and economically-sound for the …

Mekanisme Hubungan Sosial Ekonomi, Pemanfaatan Pelayanan Kesehatan Dan Kehamilan Risiko Tinggi Terhadap Prevalensi Panjang Badan Lahir Pendek, Demsa Simbolon, Wahyu Dwi Astuti, Lusi Andriani

Kesmas

Prevalensi panjang badan lahir pendek di Indonesia masih tinggi dan menjadi masalah kesehatan masyarakat yang disebabkan oleh pelbagai faktor secara langsung dan tidak langsung serta berdampak luas dan berkelanjutan dalam siklus kehidupan. Penelitian menggunakan data Riset Kesehatan Dasar (Riskesdas) 2013 dengan pendekatan potong lintang bertujuan mengetahui mekanisme hubungan berbagai variabel laten terhadap prevalensi panjang badan lahir pendek. Sampel adalah 497 kabupaten yang diagregat dari data individu, yaitu anak lahir dari ibu berusia 15 hingga 49 tahun dengan kriteria anak kandung dan lahir tunggal. Pemodelan menggunakan Structural Equation Modelling. Kehamilan berisiko tinggi berhubungan positif langsung dengan prevalensi panjang badan lahir pendek …

Maternal Fish Oil Supplementation In Pregnancy: A 12 Year Follow-Up Of A Randomised Controlled Test, Suzanne Meldrum, Janet A. Dunstan, Jonathon K. Foster, Karen Simmer, Susan L. Prescott

Research outputs 2014 to 2021

A number of trials have been undertaken to assess whether the intake of omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) during pregnancy can influence the neurological development of the offspring, yet no consensus from these trials has been reached. We aimed to investigate the long-term effects (12 years) of fish oil supplementation in pregnancy on neurodevelopment, including cognition, language and fine motor skills. In a follow up of a previously published randomised controlled trial of 98 pregnant women, their children were assessed at 12 years of age using a battery of neurodevelopmental assessments. Fifty participants were assessed at 12 years, …

Relationships Between A Prenatal Nutrition Education Intervention And Maternal Nutrition In Ethiopia, Divya Lakshmi Selvakumar

Walden Dissertations and Doctoral Studies

In Ethiopia, 17% of pregnant women ages 18-49 are malnourished and have low awareness of prenatal nutrition, which may relate to increasingly high rates of maternal and infant mortality. The purpose of this mixed methods research study was to determine the effects of a community-based prenatal nutrition education intervention program on maternal nutrition knowledge and attitudes in the Alaje district of Ethiopia. The theoretical framework was Sen's capability theory of poverty, in which opportunities can lead to well-being and promote economic development. Research questions focused on the relationships among 8 independent variables-age, income source, degree of program implementation, marital status, …

Folic Acid Awareness Among Byu Females, Natasha Bushnell, Mariana Chiriac, Nora Nyland

Journal of Undergraduate Research

One of the B vitamins, folic acid is involved in DNA synthesis in the human body. This nutrient becomes crucial during the embrionic development of the fetus during a pregnancy. A maternal deficiency of folic acid, added to a genetic predisposition, has been linked to the development of neural tube defects in the fetus (e.g. spina bifida and anencephaly). These conditions re results of an incomplete development of the central nervous system, causing 2500 to 3000 infants in the US to be physically and mentally impaired every year.

Status Gizi Ibu Dan Berat Badan Lahir Bayi, Khaula Karima, Endang Laksmining Achadi

Kesmas

Berat badan lahir 2.500 gram yang hingga kini merupakan standar ukuran risiko morbiditas dan mortalitas bayi merupakan faktor risiko penting yang berdampak hingga usia dewasa. Saat ini, bayi dengan berat badan lahir di bawah 3.000 gram dihubungkan dengan risiko penyakit degeneratif pada usia dewasa. Penelitian ini bertujuan mengetahui hubungan berat badan lahir dengan status gizi ibu meliputi berat badan prahamil, pertambahan berat badan selama kehamilan, dan kadar hemoglobin ibu pada trimester ketiga kehamilan. Penelitian kuantitatif dengan desain cross sectional ini menggunakan sumber data sekunder rekam medis Rumah Sakit Ibu dan Anak Budi Kemuliaan Jakarta. Analisis dilakukan secara bivariat dan multivariat …

Changes In Dairy Food And Nutrient Intakes In Australian Adolescents, Carole Parker, Wendy Vivian, Wendy H. Oddy, Lawrie J Beilin, Trevor A. Mori, Therese O'Sullivan

Research outputs 2012

Dairy nutrients, such as calcium, are particularly important in adolescence, a critical time for growth and development. There are limited Australian data following individuals through adolescence, evaluating changes in dairy nutrient and dairy product consumption. We used a validated food frequency questionnaire to investigate consumption in adolescents participating in both the 14 and 17 year follow-ups of the Western Australian Pregnancy Cohort (Raine) Study. Most adolescents did not reach age and gender specific recommended daily intakes for calcium or magnesium at 14 years, and this decreased as they aged to 17 years (from 33.0% to 29.2% meeting for calcium, P < 0.05, and from 33.6% to 20.5% meeting for magnesium, P < 0.01). Mean intakes of calcium, potassium, riboflavin and vitamin A also decreased with age (P < 0.01). Mean dairy intake decreased from 536 ± 343 g/day to 464 ± 339 g/day (P < 0.01), due mostly to a decrease in regular milk, although flavoured milk consumption increased in boys. Cheese and butter were the only products to show a significantly increased consumption over the period. Girls decreased from 2.2 to 1.9 serves/day of dairy, while boys remained relatively steady at 2.9 to 2.8 serves/day. Our findings suggest that dairy product consumption decreases over adolescence. This may have implications for bone mass, development and later health.

It Takes At Least Two: Male Partner Factors, Racial/Ethnic Disparity, And Chlamydia Trachomatis Among Pregnant Women, Jessica Weisz, Sara Lozyniak, Sandra D. Lane, Robert Silverman, Kathy Demott, Martha A. Wojtowycz

Falk College Research Center

Chlamydia trachomatis (CT), the most prevalent sexually transmitted infection in the United States, disproportionately infects women and people of color. This study aimed to identify risk factors for racial and ethnic disparities for CT infection, re-infection, and persistent infection among pregnant women. We present a secondary analysis of births from a retrospective cohort study in Syracuse, NY from January 2000 through March 2002. African American women [OR 3.35 CI (2.29, 4.92)], Latin American women [OR 4.35 CI (2.52, 7.48)], unmarried women [OR 7.57 CI (4.38, 13.10)], and teen mothers [OR 3.87 CI (2.91, 5.16)] demonstrated statistically significant increased risk for …

Contributing Factors To Excess Weight Gain During Pregnancy Among Low Income Women In Utah, Tianna Noelle Watson

Theses and Dissertations

Objective: To evaluate factors influencing excessive weight gain during pregnancy and changes in eating patterns from the pre-pregnancy period among low-income women (<185% poverty level). Design, Setting, & Participants: Low-income women who were at least 7-months pregnant and gained excess weight (n= 14) or normal weight (n=15) were interviewed. Questions pertained to previous nutritional knowledge, eating patterns, and sources for obtaining nutrition information.
Outcome Measures and Analysis: Transcripts were coded independently by two researchers, with any differences reconciled. Common themes were discussed and tallied to determine the most commonly re-occurring topics reported in the interviews.
Results: Most of the excess weight gainers …

Efficacy Of Different Educational Methods For A High School Prenatal Substance Use Prevention And Nutrition Program., Kimberly Renee Webb

Electronic Theses and Dissertations

The purpose of this study was to increase knowledge of the effects of prenatal substance use and to introduce the special nutritional needs of pregnancy in two counties in a region with high rates of low birth weight and prenatal substance abuse. A comparison of the efficacy of the educational program being delivered by a registered dietitian or by a group of high school students trained by the dietitian was performed. One hundred six high school students participated in the program and took identical pre- and posttests. The tests were compared to measure knowledge gain and were analyzed by paired …

The Maternal Diet Can Prevent Neural Tube Defects, Shannon Michelle Gardner

Undergraduate Honors Capstone Projects

Maternal diet and nutritional status have a direct impact on pregnancy course and outcome. Nutrition is critical to the development of the human embryo and fetus. Each year in the United States, approximately 4000 pregnancies are affected by neural tube defects (NTD). The most important finding in recent years has been the relationship between maternal folic acid status and NTDs. Other studies have found an association between zinc deficiency and an increased risk for having an NTD-affected pregnancy. Furthermore, some of the latest research has linked maternal obesity with the development of NTDs. The cumulative data from several studies have …

The Relationship Of Molybdenum To Iron Status In Pregnancy And Anemia In Rats And Humans, Jo Ann Mortensen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Weanling male rats were made anemic and fed diets supplemented with 20 ppm iron and/or 2 ppm molybdenum. A decrease in serum iron was observed in the rats supplemented only with iron and a significant decrease in hemoglobin was observed in rats given no supplementation.

In a second experiment, pregnant female rats were also fed diets supplemented with 20 ppm iron and/or 2 ppm molybdenum. An inverse relationship was apparent between iron and copper in both the serum and the liver of the female rats. The livers of their pups displayed an inverse relationship between molybdenum and copper. Hemoglobin in …

Nutrition During Pregnancy, Lactation And Infancy, Minodokht Froozani

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

In many countries in South and East Asia, most diets are defective in quality, even when there is not a severe shortage of food. They do. not provide an adequate quantity of essential nutrients. One of the most severe deficiencies is in good quality protein. The solution to this problem is to produce and provide the right kinds of foods and to establish national food production policies which should make it possible to plan a better balanced diet based on sound nutritional principles and modern knowledge of nutritional requirements. Some degree of undernutrition, over-nutrition, or malnutrition occurs in most European …