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Rapid Gut Transit Time And Slow Fecal Isoflavone Disappearance Phenotype Are Associated With Greater Genistein Bioavailability In Women, Yan Zheng, Jiang Hu, Patricia A. Murphy, D. Lee Alekel, Warren D. Franke, Suzanne Hendrich
Rapid Gut Transit Time And Slow Fecal Isoflavone Disappearance Phenotype Are Associated With Greater Genistein Bioavailability In Women, Yan Zheng, Jiang Hu, Patricia A. Murphy, D. Lee Alekel, Warren D. Franke, Suzanne Hendrich
Warren D Franke
The bioavailability of soybean isoflavones varies widely among individuals due to many factors, including activities of gut microflora. To characterize factors that affect fecal isoflavone disappearance phenotype and isoflavone bioavailability in women, 35 Asian and 33 Caucasian women, 18-43 y of age, provided fecal samples for anaerobic incubation with isoflavones in vitro at two times 5 mo apart (Phases I and II). Diet, physical activity and health history were investigated at these times. A single dose of soymilk powder [1.2 mg (4.57 micromol) total isoflavone/kg body] was given to all subjects with breakfast in phase II. Daidzein and genistein from …