Nutrition Commons^™

Predicting Sedentarism And Its Impact On Caloric Requirements, Jacob Michels, John C. Beghin

Yeutter Institute International Trade Policy Review

A recent study conducted by PhD candidate Jacob Michels and Agricultural economist John Beghin delves into the question of whether global estimates of food insecure populations need a reevaluation of their methodology to account for increasing sedentarism. This reevaluation is prompted by the increasing prevalence of sedentary lifestyles worldwide, which calls for a redefinition of caloric thresholds indicating the onset of food insecurity. In this short article, we provide a nontechnical summary of their investigation recently published in Michels and Beghin (2024).

Descriptive Report On Dietary Remains From Aztec And Salmon Ruins Coprolites, Karl J. Reinhard

Karl Reinhard Publications

This report focuses only on dietary results from the Aztec Ruins and Salmon Ruins coprolites. The parasitological analysis was completed in 2018 and was the focus of several papers that were summarized by Camacho and Reinhard (2020). This did not include DNA analysis. The coprolites from these sites are not appropriate sources of DNA testing.

The main conclusion of the analysis are:

1) Two very distinct plant spectra are represented in Aztec Ruins West (ARW) room 219 and room 225.

2) The three contexts of ARW room 219 show interesting variation in food selection, however these are small samples.

3) …

Feed Value And Utilization Of Corn Residue: Implications For Cow Performance And Grazing Strategies, Kaylee E. Wheeler

Department of Animal Science: Dissertations, Theses, and Student Research

Two experiments were conducted to determine the correlation of corn residue feed value and utilization on cow performance and potential grazing strategies. A qualitative observation of corn residue grazing by 13 cattle herds across Nebraska was conducted over two years. Based on producer reported grain yields and stocking rates, it was found that these producers were generally not as aggressive as the recommended 1.2 animal unit months (AUM) for each 6,280 kg/ha (100 U.S. bushels/acre) of harvested grain. They stocked 17 to 101% of the recommendation and on average used 63% of the carrying capacity. Across herds, average body condition …

Predicting Body Weight Of Cattle And Nutrient Digestion Of Individual Sweet Bran Components To Improve Beef Cattle Production Efficiency, Dalton J. Anderson

Department of Animal Science: Dissertations, Theses, and Student Research

Efficiency is of high importance to beef cattle producers to ensure that beef cattle are being raised without unnecessary resource use. Two separate experiments were conducted to evaluate potential strategies to improve efficiency in beef cattle production. A metabolism study was conducted to evaluate digestion parameters of individual Sweet Bran components. The objective was to determine the effects of diet components on nutrient digestion and rumen fermentation parameters. The individual components of Sweet Bran (Corn bran, solvent-extracted germ meal, and corn steep liquor) were included at 40% diet dry matter (DM) in a steam-flaked corn (SFC) based diet. A SFC-based …

The Evaluation Of Feed Additives On Reducing Enteric Methane Production From Cattle, Reba L. Colin

Department of Animal Science: Dissertations, Theses, and Student Research

Environmental sustainability can be positively impacted by the inclusion of feed additives to reduce enteric methane production from cattle. Methane production can be affected by feed additives that either alter the rumen environment or act as methanogenesis inhibitors. A reduction in methane from cattle can contribute to meeting carbon neutrality.

A metabolism study was conducted to evaluate Alga 1.0, a product containing bromoform, fed to cattle to evaluate the effects on gas emissions. Treatments were (0, 69, or 103 g/d Alga 1.0) fed in a corn-based diet. Headbox-style indirect calorimeters were used to measure gas emissions. Feeding Alga 1.0 linearly …

The Impact Of Silage Inclusion In Diets With Different Corn Processing And The Effect Of Natural And Conventional Feeding Programs On Finishing Cattle Performance, Jessica L. Miller

Department of Animal Science: Dissertations, Theses, and Student Research

A finishing experiment was conducted to determine the effects of natural and conventional feeding programs on finishing performance of steers and heifers. Factors were conventional and natural feeding programs in steers and heifers. Cattle assigned to the conventional program were fed diets that contained Rumensin (Elanco Animal Health), Tylan (Elanco Animal Health), MGA (Zoetis), and received growth promoting implants whereas cattle in the natural program received neither. Compared to natural fed cattle, G:F was improved by 15.5% when heifers were fed in a conventional program (P < 0.01) and 23.8% when steers were fed in a conventional program (P < 0.01). The incorporation of implants and feed additives within the finishing period increased …

Forages And Technology Management In Growing And Finishing Beef Cattle Systems, Kelton Cole Adair

Department of Animal Science: Dissertations, Theses, and Student Research

A systems study evaluated the effects of an implant [25.7 mg estradiol (Compudose; Elanco Animal Health)] at two rates of gain (LOW: 0.45 kg/d and HIGH: 0.9 kg/d) applied during the winter backgrounding phase in drylot and winter grazing systems and its effects on subsequent phases of production. HIGH supplementation with an implant during the winter backgrounding phase in the drylot system yielded the greatest ending body weight (EBW) during the summer backgrounding phase (P = 0.04). LOW supplementation, without an implant, improved summer backgrounding average daily gain (ADG; P = 0.05) while achieving similar carcass adjusted final body …

Factors Affecting Forage Quality And The Subsequent Response In Production And Energy Metabolism In Lactating Jersey Cows, Kassidy Kate Buse

Department of Animal Science: Dissertations, Theses, and Student Research

Forage quality is the potential of a forage to produce a production response in animals. Because of how essential they are in dairy cattle rations, forages can have major influence on the behavior and production of dairy cattle. In experiment 1, the effect of forage fragility on the rumen environment and digestibility was evaluated. Increasing the inclusion of a less fragile forage led to greater rumen retention time, which resulted in lower rumen pH and greater NDF digestibility. Experiment 2 evaluated the effects of diets high in either corn silage or alfalfa haylage supplemented with either corn- or soybased protein …

Early-Life Supplementation Of Omega-3 Polyunsaturated Fatty Acids Improved Growth And Skeletal Muscle Glucose Metabolism In The Heat Stress-Induced Iugr Neonatal Lamb, Melanie Ryann White

Department of Animal Science: Dissertations, Theses, and Student Research

Our 1^st study determined whether metabolic deficits of IUGR-born neonatal lambs can be improved by ameliorating elevated inflammatory tone. Supplementation with ω-3 polyunsaturated fatty acids (ω-3 PUFA) improved hindlimb insulin-stimulated glucose oxidation rates and basal lactate secretion. Ex vivo skeletal muscle-specific glucose oxidation rates were improved when heightened inflammatory tone was moderated. Pancreatic β cell function in response to hyperglycemia was improved by ω-3 PUFA supplementation. Tempered inflammatory tone also partially recovered skeletal muscle glycogen stores. Thus, we found that targeting heightened inflammatory tone inherent in IUGR-born neonatal lambs moderately improved glucose metabolism and pancreatic β cell …

Increasing Maternity Leave And Decreasing Attrition Rates Of U.S. Active Duty Women In The Prenatal And Immediate Postpartum Period, Minette S.R. Herrick, Weiwen Chai

Department of Nutrition and Health Sciences: Faculty Publications

Introduction:The USA currently does not have a national parental leave policy. In 2016, the Secretary of Defense increased the allotted maternity leave for active duty U.S. military members from 6 to 12 weeks. The purpose of this study was to understand the potential impact of this change on attrition rates of active duty women in the Army, Air Force, Navy, and Marines from their initial prenatal visit through the first year postpartum.

Methods: All active duty women who had a confirmed pregnancy in the electronic health record from 2011 to 2019 were included for consideration in the study. …

Characterization And Evaluation Of Bioactivity Of Dry Edible Bean And Bean Derived Small Peptides, Bikram Prasad Upadhyaya

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Obesity, diabetes, and their metabolic complications continue to be one of the major global public health concerns with a few effective treatment options. Although regular exercise and a well-balanced diet that includes calories from pulses can be recommended, much remains to be elucidated about the health effects of the various bioactive compounds including peptides and polyphenols present in pulses. Most of the previous studies have focused on individual dietary compounds and only a few investigated the synergistic effect of active compounds in modulating human health. Hence this dissertation aimed first, to provide a comparative evaluation of the overall therapeutic value …

Milk-Borne Small Extracellular Vesicles: Kinetics And Mechanisms Of Transport, Distribution, And Elimination, Alice Ngu, Javaria Munir, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Small extracellular vesicles (sEVs) in milk have the qualities desired for delivering therapeutics to diseased tissues. The production of bovine milk sEVs is scalable (10²¹ annually per cow), and they resist degradation in the gastrointestinal tract. Most cells studied to date internalize milk sEVs by a saturable process that follows Michaelis-Menten kinetics. The bioavailability of oral milk sEVs is approximately 50%. In addition to crossing the intestinal mucosa, milk sEVs also cross barriers such as the placenta and blood-brain barrier, thereby enabling the delivery of therapeutics to hard-to-reach tissues. In time course studies, levels of milk sEVs peaked in …

Kluyveromyces Marxianus Prepared As A Ready To Use Supplemental Food (Rusf), Zachary Christman

Applied Science Program: Theses

Ready to Use Supplemental Food (RUSF) is a nutrient dense paste or compressed bar used to supplement a person’s nutritional needs because of malnutrition or due to food shortages. The purpose of this article is to demonstrate some methods of how the dairy organism Kluyveromyces marxianus can be used to enrich the protein value of bread or ferment a substrate such as wheat bran into a more digestible form.

Resistance Training In Humans And Mechanical Overload In Rodents Do Not Elevate Muscle Protein Lactylation, Madison L. Mattingly, Auburn University A. Ruple, Casey L. Sexton, Joshua S. Godwin, Mason C. Mcintosh, Morgan A. Smith, Daniel L. Plotkin, J. Max Michel, Derick A. Anglin, Nicholas J. Kontos, Shengyi Fei, Stuart M. Phillips, C. Brooks Mobley, Ivan Jose Vechetti Jr, Christopher G. Vann, Michael D. Roberts

Department of Nutrition and Health Sciences: Faculty Publications

Although several reports have hypothesized that exercise may increase skeletal muscle protein lactylation, empirical evidence in humans is lacking. Thus, we adopted a multifaceted approach to examine if acute and subchronic resistance training (RT) altered skeletal muscle protein lactylation levels. In mice, we also sought to examine if surgical ablation-induced plantaris hypertrophy coincided with increases in muscle protein lactylation. To examine acute responses, participants’ blood lactate concentrations were assessed before, during, and after eight sets of an exhaustive lower body RT bout (n = 10 trained college-aged men). Vastus lateralis biopsies were also taken before, 3-h post, and 6-h post-exercise …

Critical Contributions Of Protein Cargos To The Functions Of Macrophage‑Derived Extracellular Vesicles, Baolong Liu, Phuong Linh Nguyen, Han Yu, Xingzhi Li, Huiren Wang, Wang Price, Meng Niu, Chittibabu Guda, Xiao Cheng, Xinghui Sun, Regis Moreau, Amanda E. Ramer-Tait, Michael J. Naldrett, Sophie Alvarez, Jiujiu Yu

Department of Nutrition and Health Sciences: Faculty Publications

Background Macrophages are highly plastic innate immune cells that play key roles in host defense, tissue repair, and homeostasis maintenance. In response to divergent stimuli, macrophages rapidly alter their functions and manifest a wide polarization spectrum with two extremes: M1 or classical activation and M2 or alternative activation. Extracellular vesicles (EVs) secreted from differentially activated macrophages have been shown to have diverse functions, which are primarily attributed to their microRNA cargos. The role of protein cargos in these EVs remains largely unexplored. Therefore, in this study, we focused on the protein cargos in macrophage-derived EVs.

Results Naïve murine bone marrow-derived …

Market And Welfare Impacts Of A “Portion Size Reduction” Policy, Hanin Hosni, Konstantinos Giannakas

Cornhusker Economics

The portion size of common food items consumed at home, restaurants and fast-food establishments in the United States (US) has increased since the 1970s, with the portion size of meals and beverages in several restaurants exceeding the US Department of Agriculture (USDA) and Food and Drug Administration recommendations. Portion size has continued to grow in parallel with increasing body weights and food waste. According to USDA, 35% of the US population suffers from obesity while 40 million people are food insecure. At the same time, about 1/3 of the US food supply goes unconsumed, with 2/3 of food waste occurring …

Sprouting Alters Metabolite And Peptide Contents In The Gastrointestinal Digest Of Soybean And Enhances In-Vitro Anti-Inflammatory Activity, Emerson Nolasco, Inga Krassovskaya, Kelvin Hong, Kali Hansen, Sophie Alvarez, Toshihiro Obata, Kaustav Majumder

Department of Nutrition and Health Sciences: Faculty Publications

Sprouting of soybeans can enhance the release of health-beneficial bioactive compounds, especially peptides, and metabolites, while gastrointestinal (GI) digestion alters their biotransformation and bioaccessibility. The present study aimed to evaluate the effect of soybean sprouting and GI digestion in modulating its anti-inflammatory activity. Soybeans were soaked in water overnight (Day 0) and sprouted for two and four days, subjected to simulated GI digestion, and human intestinal epithelial cells (Caco-2) were pretreated (2 h) with soybean sprout digest (SSD: 1000 μg/mL) before inflammation induction with IL-1β. Pre-treatment with Day 4 SSD specifically reduced the secretion of cytokine IL-8 by 19.5%. Sprouting …

Protein Enriched Bread Using Spent Wine Yeast, Zachary Christman

Applied Science Program: Theses

Yeast is a common byproduct of wine production. Wine yeast may be used as a food source. It does not contain bitter and astringent compounds such as those present in spent yeast from making beer The use of nutritional yeast and yeast extract for protein enrichment of bread are presented in this article.

Antibiotic-Induced Gut Dysbiosis And Cognitive, Emotional, And Behavioral Changes In Rodents: A Systematic Review And Meta-Analysis, Shivdeep S. Hayer, Soonjo Hwang, Jonathan B. Clayton

Department of Nutrition and Health Sciences: Faculty Publications

There are previous epidemiological studies reporting associations between antibiotic use and psychiatric symptoms. Antibiotic-induced gut dysbiosis and alteration of microbiota-gut-brain axis communication has been proposed to play a role in this association. In this systematic review and meta-analysis, we reviewed published articles that have presented results on changes in cognition, emotion, and behavior in rodents (rats and mice) after antibiotic-induced gut dysbiosis. We searched three databases—PubMed, Web of Science, and SCOPUS to identify such articles using dedicated search strings and extracted data from 48 articles. Increase in anxiety and depression-like behavior was reported in 32.7 and 40.7 percent of the …

Resistant Potato Starch Supplementation Reduces Serum Histamine Levels In Healthy Adults With Links To Attenuated Intestinal Permeability, Jason R. Bush, Jun Han, Edward C. Deehan, Scott V. Harding, Madhura Maiya, Joshua Baisley, David Schibli, David R. Goodlett

Department of Nutrition and Health Sciences: Faculty Publications

Histamine from our diet or gut microbes can trigger gastrointestinal disturbances, and resistant potato starch (RPS) has previously been shown to alleviate these symptoms while increasing levels of health-associated bacteria such as Akkermansia through unknown mechanisms. Post hoc exploratory metabolomic analysis of serum amino acid, amine, and carnitine metabolites in participants consuming 3.5 g/day RPS or placebo (n = 48) was performed using liquid chromatography-mass spectrometry to determine whether RPS positively influences histamine metabolism and related parameters. Histamine levels were significantly reduced by RPS treatment, but histamine-degrading enzyme products were unaffected by RPS. RPS also reduced histamine-secreting Haemophilus and Lactobacillus …

Fatiguing Joint Angle Does Not Influence Torque And Neuromuscular Responses Following Sustained, Isometric Forearm Flexion Tasks Anchored To Perceptual Intensity In Men, Dolores G. Ortega, Terry J. Housh, Robert Smith, Jocelyn E. Arnett, Tyler J. Neltner, John Paul V. Anders, Richard J. Schmidt, Glen O. Johnson

Department of Nutrition and Health Sciences: Faculty Publications

This study examined the effects of joint angle (JA) on maximal voluntary isometric contraction (MVIC) and neuromuscular responses following fatiguing tasks anchored to RPE. Nine men (mean ± SD: age = 20.7 ± 1.2 yrs) performed forearm flexion MVICs at elbow JAs of 75^o and 125^o before and after sustained, isometric forearm flexion tasks to failure at fatiguing joint angles (FJA) of 75^o and 125^o anchored to RPE = 8. The amplitude and frequency of the electromyographic and mechanomyographic signals were recorded. Neuromuscular efficiency was calculated by dividing normalized torque by normalized electromyographic amplitude. A dependent …

Auricularia Auricula Polysaccharides Attenuate Obesity In Mice Through Gut Commensal Papillibacter Cinnamivorans, Xin Zong, Hao Zhang, Luoyi Zhu, Edward C. Deehan, Jie Fu, Yizhen Wang, Mingliang Jin

Department of Nutrition and Health Sciences: Faculty Publications

Introduction: Auricularia auricula is a well-known traditional edible and medical fungus with high nutritional and pharmacological values, as well as metabolic and immunoregulatory properties. Nondigestible fermentable polysaccharides are identified as primary bioactive constituents of Auricularia auricula extracts. However, the exact mechanisms underlying the effects of Auricularia auricula polysaccharides (AAP) on obesity and related metabolic endpoints, including the role of the gut microbiota, remain insufficiently understood.

Methods: The effects of AAP on obesity were assessed within high-fat diet (HFD)-based mice through obesity trait analysis and metabolomic profiling. To determine the mechanistic role of the gut microbiota in observed anti-obesogenic …

Consequences Of Cow–Calf Production With Limited Perennial Forage Grazing, Hannah Fae Speer

Department of Animal Science: Dissertations, Theses, and Student Research

Conversion of perennial grasslands to cropland and rising land prices prompts a need to evaluate alternative beef cow-calf production systems. A 3-yr study was conducted comparing beef cow-calf performance between two August-calving cow systems: perennial forage and corn residue grazing; or summer drylot, fall grazing of late-summer-planted cover crop, and corn residue grazing. Cow body condition score differed between systems, but condition of cows in both systems never fell below adequate. There were no differences in pregnancy rates between systems. Calf weaning weights differed between systems each year; differences are attributed to feedstuff quantity, quality, and type available to calves …

Performance Fatigability And Neuromuscular Responses Are Not Joint Angle Specific Following A Sustained Isometric Forearm Flexion Task Anchored To A High Perceptual Intensity In Women, Jocelyn E. Arnett, Robert W. Smith, Tyler J. Neltner, John Paul V. Anders, Dolores G. Ortega, Terry J. Housh, Richard J. Schmidt, Glen O. Johnson

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: To examine the effects of joint angle (JA) on maximal voluntary isometric contractions (MVIC) and neuromuscular responses following a sustained, isometric forearm flexion task anchored to a rating of perceived exertion (RPE) of 8 (RPE=8). Methods: Nine women (age: 20.7±2.9 yrs; height: 168.8±7.2 cm; body mass: 66.3±6.8 kg) performed 2,3s forearm flexion MVICs at JAs of 75°, 100°, and 125° prior to and following a sustained, isometric forearm flexion task anchored to RPE=8 to task failure (torque reduced to zero) at JA100. Electromyographic (EMG) and mechanomyographic (MMG) signals were recorded from the biceps brachii. Results: The …

Homeobox Transcription Factor Hbxa Influences Expression Of Over One Thousand Genes In The Model Fungus Aspergillus Nidulans, Sandesh S. Pandit, Jinfang Zheng, Yanbin Yin, Sophie Lorber, Olivier Puel, Sourabh Dhingra, Eduardo A. Espeso, Ana M. Calvo

Department of Nutrition and Health Sciences: Faculty Publications

In fungi, conserved homeobox-domain proteins are transcriptional regulators governing development. In Aspergillus species, several homeobox-domain transcription factor genes have been identified, among them, hbxA/hbx1. For instance, in the opportunistic human pathogen Aspergillus fumigatus, hbxA is involved in conidial production and germination, as well as virulence and secondary metabolism, including production of fumigaclavines, fumiquinazolines, and chaetominine. In the agriculturally important fungus Aspergillus flavus, disruption of hbx1 results in fluffy aconidial colonies unable to produce sclerotia. hbx1 also regulates production of aflatoxins, cyclopiazonic acid and aflatrem. Furthermore, transcriptome studies revealed that hbx1 has a broad effect on the A. flavus …

Sesame Eliciting And Safe Doses In A Large Sesame Allergic Population, Liat Nachshon, Joost Westerhout, W. Marty Blom, Benjamin Remington, Michael B. Levy, Michael R. Goldberg, Naama Epstein-Rigbi, Yitzhak Katz, Arnon Elizur

Department of Nutrition and Health Sciences: Faculty Publications

Background: Sesame is a significant food allergen causing severe and even fatal reactions. Given its increasing prevalence in western diet, sesame is listed as an allergenic food requiring labeling in the United States and EU. However, data on the population reaction doses to sesame are limited.

Methods: All sesame oral food challenges (OFCs), performed either for diagnosis or for threshold identification before the beginning of sesame oral immunotherapy (OIT) between November 2011 and July 2021 in Shamir medical center were analyzed for reaction threshold distribution. Safe-dose challenges with 90–120 min intervals were also analyzed.

Results: Two hundred …

Assessment Of The Immune Response In Patients With Insulin Resistance, Obesity, And Diabetes To Covid-19 Vaccination, Jędrzej Warpechowski, Paula Leszczyńska, Dominika Juchnicka, Adam Olichwier, Łukasz Szczerbiński, Adam Jacek Krętowski

Department of Nutrition and Health Sciences: Faculty Publications

The SARS-CoV-19 pandemic overwhelmed multiple healthcare systems across the world. Patients with underlying medical conditions such as obesity or diabetes were particularly vulnerable, had more severe symptoms, and were more frequently hospitalized. To date, there have been many studies on the severity of SARS-CoV-2 in patients with metabolic disorders, but data on the efficiency of vaccines against COVID-19 are still limited. This paper aims to provide a comprehensive overview of the effectiveness of COVID-19 vaccines in individuals with diabetes, insulin resistance, and obesity. A comparison is made between the immune response after vaccination in patients with and without metabolic comorbidities. …

Studies Of The Role Of Mtorc1 In Modulating Intestinal Epithelial Barrier Function, Isaac Adediji

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Mechanistic target of rapamycin complex 1 (mTORC1) signaling impacts intestinal inflammation by modulating the production of cytokines in both intestinal epithelial cells and macrophages. Recent evidence revealed that THP-1-derived macrophages with elevated mTORC1 activity (THP-1shTSC2 macrophages), exhibited increased proinflammatory cytokine production when stimulated with lipopolysaccharide (LPS) compared to counterpart macrophages with repressed or baseline mTORC1 activity. Furthermore, it has been shown that mTORC1 governs intestinal barrier function as evidenced by elevated transepithelial electrical resistance (TEER) and para/transcellular permeability in Raptor-depleted Caco-2 cells (cells with repressed mTORC1 activity) compared to Caco-2 cells with elevated or baseline mTORC1 activity. The present study …

Literature Review—Transthoracic Echocardiography, Computed Tomography Angiography, And Their Value In Clinical Decision Making And Outcome Predictions In Patients With Covid-19 Associated Cardiovascular Complications, Jędrzej Warpechowski, Adam Olichwier, Aleksandra Golonko, Marcin Warpechowski, Robert Milewski

Department of Nutrition and Health Sciences: Faculty Publications

The sudden outbreak of the COVID-19 pandemic posed a great threat to the world’s healthcare systems. It resulted in the development of new methods and algorithms for the diagnosis and treatment of both COVID-19 and its complications. Diagnostic imaging played a crucial role in both cases. Among the most widely used examinations are transthoracic echocardiography (TTE) and computed tomography angiography (CTA). Cardiovascular complications in COVID-19 are frequently associated with a severe inflammatory response, which results in acute respiratory failure, further leading to severe complications of the cardiovascular system. Our review aims to discuss the value of TTE and CTA in …

Diet-Microbiome-Immune Interplay In Multiple Sclerosis: Understanding The Impact Of Phytoestrogen Metabolizing Gut Bacteria, Peter C. Lehman, Sudeep Ghimire, Jeffrey D. Price, Amanda E. Ramer-Tait, Ashutosh K. Mangalam

Department of Nutrition and Health Sciences: Faculty Publications

Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic and environmental factors contributing to the pathobiology of the disease. Although HLA genes have emerged as the strongest genetic factor linked to MS, consensus on the environmental risk factors is lacking. Recently, the gut microbiota has garnered increasing attention as a potential environmental factor in MS, as mounting evidence suggests that individuals with MS exhibit microbial dysbiosis (changes in the gut microbiome). Thus, there has been a strong emphasis on understanding the role of the gut microbiome in the pathobiology of …