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Nutritional Epidemiology

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Full-Text Articles in Nutrition

Effectiveness Of Intervention Studies Based On Diet And/Or Physical Activity In Treatment, Prevention, And Management Of Diabetes Among South Asians: A Systematic Review, Ishaan Arora Aug 2023

Effectiveness Of Intervention Studies Based On Diet And/Or Physical Activity In Treatment, Prevention, And Management Of Diabetes Among South Asians: A Systematic Review, Ishaan Arora

Theses and Dissertations

The purpose of this study was to describe diet and/or physical activity-based interventions and their control in cardiometabolic risk factors of diabetes for the South Asian (SA) population. A systematic review was conducted in accordance with the PRISMA guidelines. Seventeen randomized control trials meeting the inclusion criteria were included for analysis. Interventions with type-2 diabetic SA showed significant improvements in HbA1c% (4/5 studies), fasting blood glucose (3/4 studies), and postprandial glucose (2/2 studies). Interventions with at-risk/prediabetic and non-diabetic SA showed a modest change in overall outcomes, with significant change reported for post-prandial insulin (3/4 studies), BMI and weight (2/4 studies), …


An Analysis On How Housing Status Influences The Gut-Brain-Axis For Populations In And Around The Skid Row Area Of Los Angeles, California, Mauricio Guzman Jan 2023

An Analysis On How Housing Status Influences The Gut-Brain-Axis For Populations In And Around The Skid Row Area Of Los Angeles, California, Mauricio Guzman

Pitzer Senior Theses

Over recent years, the “microbiota-gut-brain axis” (MGBA) has garnered significant attention in the scientific community. Specifically, perturbations of the MGBA via stress and dietary intake have been linked to a wide-range of diseases including gastrointestinal diseases, metabolic diseases, mood disorders, and cognitive diseases. However, most studies have been solely conducted on mice models and have yet to consider the more complex, intricate systems that impact the human body. In addition, researchers have yet to consider the populations who may be most susceptible to chronic stress and negative dietary outcomes. Drawing from the fields of medical sociology, non-invasive human biology, and …


Attitudes Towards Breastfeeding Among College Students At Mississippi State University, Kristin F. Williford Dec 2022

Attitudes Towards Breastfeeding Among College Students At Mississippi State University, Kristin F. Williford

Theses and Dissertations

Breastfeeding rates in America are lower than other high-income countries, with Mississippi having one of the lowest rates. A survey using the Iowa Infant Feeding Attitude Scale (IIFAS) was distributed twice to Mississippi State University students to understand their breastfeeding attitudes. Attitudes were determined by calculating a composite score and conducting statistical tests for significance. Knowledge between health and non-health related majors were explored by using five statements, and attitudes towards the statement “Breastmilk is the ideal food for babies” were compared across demographics. Of 642 respondents, the composite score was 57.3 out of 85, and all demographics had a …


Food Insecurity And Depression Among Us Adults: The National Health And Nutrition Examination Survey, Nicole Reeder May 2022

Food Insecurity And Depression Among Us Adults: The National Health And Nutrition Examination Survey, Nicole Reeder

Theses and Dissertations

Food insecurity has long been a global challenge associated with negative health outcomes. The spectrum of food insecurity corresponds to a spectrum of negative health outcomes that range from kwashiorkor and marasmus to obesity and chronic disease. The burden of food insecurity is a stressor that additionally negatively effects mental health. In this study, the relationship between food insecurity and mental health was examined using data from the National Health and Nutrition Examination Survey (NHANES). Food insecurity was assessed with the 18-item United States Food Security Survey Module, and participants were classified into one of four categories based on their …


Food Allergy Education In The Hospitality Industry, Hayley Stull May 2022

Food Allergy Education In The Hospitality Industry, Hayley Stull

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Food allergies affect thousands of people, because hospitality foodservice workers come into contact with the public, it is necessary that they need to be fully trained to ensure the safety of the public. This is especially important for those who possess food allergies. Previous research has shown major gaps in knowledge amongst these workers, which can lead to the potential to harm individuals with a food allergy. There is a lack in the consistency of training specifically concerning food allergies for food service workers across all states in the U.S. There are previous forms of educational tools concerning food allergies …


The Impact Of Dietary Protein Supplementation As Part Of A Time Restricted Feeding Eating Pattern On Sleep, Mood, And Body Composition In Adults With Overweight Or Obesity, Rebecca L. Bowie May 2022

The Impact Of Dietary Protein Supplementation As Part Of A Time Restricted Feeding Eating Pattern On Sleep, Mood, And Body Composition In Adults With Overweight Or Obesity, Rebecca L. Bowie

Graduate Theses and Dissertations

Obesity in the United States continues to increase, and effective, long-term weight loss strategies are limited. Time restricted feeding (TRF) is a dietary intervention that has potential to serve as an effective long-term weight loss strategy, however more data is needed to establish the effectiveness of a TRF eating pattern on obesity and its related health outcomes. To our knowledge, manipulation of macronutrient composition during TRF intervention and the effect of TRF on sleep and mood have not been studied. Therefore, the objective of this study was to determine the effect of protein supplementation during TRF on mood, sleep, and …


Aims: Action Against Infirmity And Malnutrition In Seniors, Maeve Lorraine Mary O'Connell Jan 2022

Aims: Action Against Infirmity And Malnutrition In Seniors, Maeve Lorraine Mary O'Connell

Theses

Aim: The primary aim of this thesis was to investigate the relationship between nutrition and frailty in Irish older adults. The nutritional status, dietary quality and perceived barriers/motivators to nutrition were also examined, and a frailty intervention protocol was designed. Methods: Cross-sectional study in Irish community-dwelling adults aged ≥65 years. Nutritional status, dietary intake, functional mobility and food choice motivators/healthy eating barriers were assessed using the Mini Nutritional Assessment – Short Form (MNA-SF), a food frequency questionnaire (FFQ), the Timed Up and Go (TUG) test and a custom designed 2-item questionnaire, respectively. Frailty was defined as three or more of …


Western Diet In Adulthood, Timing Of Menarche, And Economic Status Among Northeast Ohioans, Kailey Maroni, Anne Wiley Phd, Nicole M. Burt Phd, Randall J. Mitchell Phd Jan 2022

Western Diet In Adulthood, Timing Of Menarche, And Economic Status Among Northeast Ohioans, Kailey Maroni, Anne Wiley Phd, Nicole M. Burt Phd, Randall J. Mitchell Phd

Williams Honors College, Honors Research Projects

I studied the age at first menstruation as a predictor of Western diet consumption among adults at The University of Akron and in Cleveland. I used stable carbon and nitrogen isotope compositions of human hair, as well as surveyed consumption of foods important to a Western diet (red meat, sugar, and dairy), to understand whether participants aligned with a Western dietary pattern. Age at survey and adult economic status were investigated as potential confounding variables. My data analysis and conclusions for this project has been completed and approved by my advisor and committee. To maintain collaborators' ability to publish a …


Food Insecurity In Vermont Households: An Analysis Of The Association With Tobacco Use, Alcohol Consumption And Physical Inactivity, Hannah R. Kaufman, Kyleigh Savoie, Emily Belanger, Kijonna Bowman, Darren Childs, Hendrika Maltby Jan 2021

Food Insecurity In Vermont Households: An Analysis Of The Association With Tobacco Use, Alcohol Consumption And Physical Inactivity, Hannah R. Kaufman, Kyleigh Savoie, Emily Belanger, Kijonna Bowman, Darren Childs, Hendrika Maltby

Master of Public Health Culminating Projects

Objectives: To assess the relationship between chronic disease risk behaviors: tobacco usage, alcohol consumption, sedentary lifestyle, and food insecurity (FI) among Vermonters. Methods: This cross-sectional study uses a sample (n= 1,378) from Vermont’s 2018 Behavioral Risk Factor Surveillance System (BRFSS). The examined outcome is FI. The predictor measures were defined as at-risk tobacco use, alcohol consumption, and sedentary lifestyles.The following were established as covariates on the association between the dependent and independent variables: income, sex, age, race/ethnicity, and activity limitations. Results: In the unadjusted binomial logistic regression (Table 2), tobacco users were 3.32 times more likely to be food …


Osteoporosis Prevention Is Linked To Education, Childhood Meals And Milk Consumption In Young Adult Females, Karen E. From Jan 2021

Osteoporosis Prevention Is Linked To Education, Childhood Meals And Milk Consumption In Young Adult Females, Karen E. From

UNF Graduate Theses and Dissertations

The three aims of the study investigated the females’ age 18-25 perception, knowledge, and health beliefs, barriers and strategies to overcoming barriers to prevent osteoporosis. The mixed method explanatory design of research was implemented. Phase one used a survey to gather demographic data, past and current behaviors, the completion of the Osteoporosis Health Behavior Scale (OHBS) questionnaire, and Short Calcium Intake List (SCaIL). Four hundred forty-nine quality survey responses were obtained. The second phase, the focus group (n=23), discussed questions designed to answer the three aims of the study. Results- Our analysis showed 90% of our 447 survey participants did …


The Association Of The Inflammatory Potential Of Diet With Inflammation And Depression Among U.S. Adults: Nhanes 2005-2010, Deniz Azarmanesh Dec 2020

The Association Of The Inflammatory Potential Of Diet With Inflammation And Depression Among U.S. Adults: Nhanes 2005-2010, Deniz Azarmanesh

Doctoral Dissertations

Depression affects 8% of adults in America. Women are twice as likely as men to experience depression. The economic burden in the U.S. is $83 billion in direct (e.g., pharmaceutical) and indirect costs (e.g., absenteeism from work). The etiology of depression includes non-modifiable (e.g., genetics) and modifiable risk factors (e.g., diet). Depression is concurrent with an increase in inflammatory biomarkers, such as c-reactive protein (CRP). Emerging research suggests that a pro-inflammatory diet may increase odds of experiencing depression. The Dietary Inflammatory Index (DII) assesses the inflammatory potential of diet. According to our narrative review of the current literature in Chapter …


Effects Of Commercial Feed Additives On Growth Performance And Gut Microbiota Of Nursery Pigs, Xiaoyuan Wei Dec 2020

Effects Of Commercial Feed Additives On Growth Performance And Gut Microbiota Of Nursery Pigs, Xiaoyuan Wei

Graduate Theses and Dissertations

To secure animal welfare and maximum production, feed additives are often added to nursery pig diets to increase nutrition digestibility, enhance intestinal health, and prevent or mitigate disease, with the ultimate goal of improving growth performance. This thesis performed a longitudinal analysis using next-generation sequencing to investigate the dynamic changes of gut microbiota in weaned pigs fed commercial feed additives. Chapter II was used to evaluate the effects of organic acid mixture on growth performance and gut microbiota of weaning pigs. This study demonstrated that the inclusion of 0.035% (SBA0.035) or 0.070% (SBA0.070) sodium butyrate in a diet containing 0.5% …


Examining The Correlates Of Adolescent Food And Nutrition Knowledge In London, Ontario, Rachel Ann Brown Aug 2020

Examining The Correlates Of Adolescent Food And Nutrition Knowledge In London, Ontario, Rachel Ann Brown

Electronic Thesis and Dissertation Repository

Food literacy is a set of skills and knowledge that are integral to diet. It is common among teenagers to not have basic food literacy skills needed to consume a healthy diet. This exploratory study examined: (1) the current state of food and nutrition knowledge among adolescents in grades 9-12 in the London-Middlesex region of Ontario; and (2) predictors of food knowledge among adolescents. Data for this study were drawn from baseline youth and parent survey data collected for the SmartAPPetite project, a smartphone application-based intervention study which aims to improve food and nutrition knowledge and dietary habits of adolescents. …


Elucidating The Relation Between Human Milk Fatty Acids, Extracellular Vesicles, And Infant Developmental Outcomes In The First Year Of Life, Diana Bickmore Aug 2020

Elucidating The Relation Between Human Milk Fatty Acids, Extracellular Vesicles, And Infant Developmental Outcomes In The First Year Of Life, Diana Bickmore

Food Science (MS) Theses

For most infants, human milk is the recommended source of nutrition. Improved developmental outcomes have been reported in infants that consume human milk compared to infant formula. Essential fatty acids (EFAs) confer health benefits. However, EFAs cannot be synthesized by the body, and therefore must be consumed in diet. Extracellular vesicles (EVs) are nanoparticles containing a lipid bilayer membrane and are present in human milk. Methods of EV isolation such as ultracentrifugation (UC) may not be feasible for the study of EVs in human milk due to the need for large sample volume, which may not be available. The objectives …


Effects Of Broccoli And Carrots On Fecal Microrna Expression In Infants: A Short-Term Feeding Study, Kaleigh E. Beane Jul 2020

Effects Of Broccoli And Carrots On Fecal Microrna Expression In Infants: A Short-Term Feeding Study, Kaleigh E. Beane

Graduate Theses and Dissertations

Diets, through multiple mechanisms, cause significant impact on human health and disease etiology; proposed modes of action include modulation of non-coding RNAs and influences on the gut microbiome. Specifically, phytochemicals change human miRNA expression thereby impacting gut microbiome and/or increasing host immune functions. Apiaceous and cruciferous vegetables have been linked to decreased chronic inflammation, which is closely related with the host immune system, yet it is not investigated how these two classes of vegetables influence the colonic miRNA profile. In this study, therefore we aimed to determine the effects of short-term feeding of broccoli and carrot to infants on fecal …


Screening For Iron-Deficiency Anemia In The Pediatric Population (Ages 1-17) In Gonaïves, Haiti, Cara Rose Fratianni May 2020

Screening For Iron-Deficiency Anemia In The Pediatric Population (Ages 1-17) In Gonaïves, Haiti, Cara Rose Fratianni

Doctor of Nursing Practice Final Manuscripts

Abstract

Purpose: The purpose of this pilot project is to screen for iron-deficiency anemia in pediatric patients (ages 1-17) in a primary school in Gonaïves, Haiti. Patients with anemia will be treated with oral supplemental iron for a period of four weeks according to WHO guidelines (WHO, 2011). All students will be treated empirically for helminths per WHO guidelines, unless treated elsewhere in the last six months (WHO, 2017). Nutritional status will also be assessed using MUAC according to WHO guidelines (2017).

Background Summary: Malnutrition contributes significantly to the problem of iron-deficiency anemia, with one in four children exhibiting stunting …


Association Of Micronutrient Inadequacy And Body Mass Index In Young Adults, Taylor Peabody May 2020

Association Of Micronutrient Inadequacy And Body Mass Index In Young Adults, Taylor Peabody

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Background

Micronutrient inadequacy has been found at higher levels in overweight and obese individuals in a broad range of ages relative to healthy weight. Insufficient micronutrient levels can have a negative impact on physical and mental health along with excess weight.

Objective

Due to health consequences related to inadequate micronutrient intake and the understanding that the general population not only fails to meet the majority of micronutrient recommendations, but is also overweight or obese, the objective of this study is to first, determine if young adults in the Northwest Arkansas Region are consuming adequate levels of micronutrients and second, if …


Efficacy Of Multivitaim-Mineral Supplementation On Health-Related Quality Of Life And Physical Activity In Young Adults, Sarah Pendergraft May 2020

Efficacy Of Multivitaim-Mineral Supplementation On Health-Related Quality Of Life And Physical Activity In Young Adults, Sarah Pendergraft

Graduate Theses and Dissertations

Micronutrients are essential for both physical and mental health. There is a correlation between poor health and mood and micronutrient deficiencies. Young adults age 18-24 are an at-risk, understudied population likely to benefit from multivitamin mineral supplementation. Multivitamin mineral supplementation is a potential way to bridge gaps in micronutrient levels, thus influencing health-related outcomes. Here, we provide the first attempt at influencing health-related quality of life and physical activity with a multivitamin mineral supplement in young adults. Using a supplement formulated without herbal extracts and caffeine, this double-blind study examined the efficacy of a daily multivitamin mineral supplement for 30 …


The Effect Of Breakfast Macronutrient Composition In Children Ages 7-17 Years Old As A Potential Method To Combat Childhood Obesity, Angela M. Tacinelli May 2020

The Effect Of Breakfast Macronutrient Composition In Children Ages 7-17 Years Old As A Potential Method To Combat Childhood Obesity, Angela M. Tacinelli

Graduate Theses and Dissertations

The prevalence of childhood overweight and obesity is an ongoing concern. Currently, approximately 20% of children in the United States are obese. While obesity was once regarded merely as excessive adiposity within the body, it is has emerged as a major risk factor for chronic diseases such as metabolic syndrome, type 2 diabetes, and cardiovascular disease. Obesity is multifactorial in nature. Weight gain can result from an energy imbalance in the body due to excess energy intake (calories in) and decreased energy expenditure (calories out). Identifying methods to combat obesity is essential. Nutritional intervention may be a strategy to help …


The Self-Perceived Impact Of A Food Recovery-Meal Delivery Program On Homebound Seniors’ Food Security, Nutrition Health, And Well-Being, Alice Marie Sanchez Jan 2020

The Self-Perceived Impact Of A Food Recovery-Meal Delivery Program On Homebound Seniors’ Food Security, Nutrition Health, And Well-Being, Alice Marie Sanchez

UNF Graduate Theses and Dissertations

For many senior citizens, meeting nutritional needs is essential to good health and daily function. Studies indicate that many American older adults are not meeting their nutrition needs and often suffer from food insecurity. Meals on Wings (MOW) is a food recovery-meal delivery program that attempts to decrease the influence of food insecurity among older adults. This study aims to explore the self-perceived impact of a food recovery-meal delivery program on homebound seniors’ nutrition health, food security, and well-being.

Semi-structured interviews were administered to adults age 55 and older on the waitlist for Meals on Wheels America in Duval County …


Intervention To Influence Healthy Eating Habits Among Dominican University Students: An Examination Of Eating Habits, Kathy Le Jan 2020

Intervention To Influence Healthy Eating Habits Among Dominican University Students: An Examination Of Eating Habits, Kathy Le

Global Public Health | Senior Theses

Food insecurity among college students has become an issue among many universities nationwide. Campus food pantries emerged to combat this problem by providing students with a diverse selection of fresh foods. Most universities are in the pilot process of their food pantries and not many studies have been done to examine the use of healthy ingredients among students. This study included 23 eligible participants who filled out pre- and post-intervention surveys as well as visited the pantry at least once during the intervention stage. The intervention was recipe posters based on the number of ingredients included, difficulty, total preparation and …


Effects Of Multivitamin-Mineral Supplementation On Mental Health Among Young Adults, Ya-Hsuan Chang Aug 2019

Effects Of Multivitamin-Mineral Supplementation On Mental Health Among Young Adults, Ya-Hsuan Chang

Graduate Theses and Dissertations

The percentage of young adults who had mental illnesses has increased from 2008 to 2015. However, few existing studies investigating the potential benefits of multivitamin-mineral (MVM) supplementation on mental health focused on young adults (18-24 years of age), whose eating behaviors are often unhealthy. The purpose of this study was to examine the effects of a MVM supplement on mental health in young adults. One hundred and thirty-three college students (Mage=20.59, SD=1.77; 80.15% female) participated in this randomized, double-blind, placebo-controlled trial. Participants consumed either a MVM supplement or a placebo for 30 days. The supplement contained B Vitamins, Vitamin C, …


Influences Of Autism Spectrum Disorder On Sensory And Emotional Responses To Smell And Taste Cues, Asmita Singh Aug 2019

Influences Of Autism Spectrum Disorder On Sensory And Emotional Responses To Smell And Taste Cues, Asmita Singh

Graduate Theses and Dissertations

Autism spectrum disorder (ASD) is a developmental disability that causes social, communication, behavioral and sensory challenges. The prevalence has been on a rise, with the latest reports stating 1 in 59 children is diagnosed with ASD. These challenges play a significant role in feeding behavior, leading to reduced nutrition among individuals. Much research in this field has been attributed to children, however, this study was focused on the adult population, in an attempt to improve their quality of life. Building on previous findings and knowledge gaps, the objectives of this thesis were two-fold: To better understand the sensory experiences of …


Increasing Food Security: Developing And Testing A Nutrition Education Curriculum For A Mobile Food Pantry, Alexandra Lepecha, Kathleen M. Kraft May 2019

Increasing Food Security: Developing And Testing A Nutrition Education Curriculum For A Mobile Food Pantry, Alexandra Lepecha, Kathleen M. Kraft

Senior Honors Projects, 2010-2019

Background: The Neighborhood Produce Market (NPM) is a food distribution model similar to a mobile food pantry. NPM stakeholders observed a lack of community engagement and familiarity with produce offered.

Project Description: The objective was to develop a nutrition education curriculum for NPM volunteers to better engage families and community members by providing food samples, recipes, and nutrition education. A stakeholder steering committee guided the needs assessment, curriculum development, volunteer training, and pilot test. The curriculum consisted of food safety, cultural considerations, and nutritional information for nine produce items and food tasting procedures and recipes. Seven student volunteers were trained …


Alcohol Use, Dietary, And Exercise Behaviors: A Latent Profile Analysis Of Young Adult Lifestyle Behaviors, Ryan Wesley Grant May 2019

Alcohol Use, Dietary, And Exercise Behaviors: A Latent Profile Analysis Of Young Adult Lifestyle Behaviors, Ryan Wesley Grant

Graduate Theses and Dissertations

As individuals enter adulthood, their lifestyles and lifestyle behaviors begin to change drastically. These lifestyle behavior changes in emerging adulthood provide a foundation for future health behaviors that often persist through all of adulthood. The aim of this study was to use Latent profile analyses (LPA) to discover distinct profiles of homogenous groups of young adults based on alcohol, diet, and exercise behaviors. Overall, five distinct profiles for both males and females were identified: Moderates, Unhealthy Eaters, Medium Drinkers, Healthier Eaters and Exercisers, and Heavy Drinkers. Heavy Drinkers and Unhealthy Eaters were the highest risk groups and reported the highest …


Micronutrient Status And Telomere Length In Adult Men And Women., Christy S. Maxwell Nov 2018

Micronutrient Status And Telomere Length In Adult Men And Women., Christy S. Maxwell

Doctoral Dissertations

Background: Telomeres are the noncoding nucleotide sequences at the end of eukaryotic chromosomes, serving to protect DNA during mitotic division. Given their guanine-rich structure, telomeres are highly susceptible to oxidative damage often mediated by inflammation. Recently, telomere attrition and dysfunction have been associated with age-related diseases, including cardiovascular disease, type 2 diabetes, Alzheimer’s disease, and certain cancers. Several modifiable risk factors have also been associated with shortened telomere length, including physical inactivity, obesity, stress, smoking, and poor diet. Objective: We examined the relations between vitamin B12 status, folate status, and iron status, relative to telomere length in …


Analysis Of Added Sugar Intake Of Canadian Children And Adolescents: Findings From The Canadian Community Health Survey On Nutrition, Ulaina Tariq Aug 2018

Analysis Of Added Sugar Intake Of Canadian Children And Adolescents: Findings From The Canadian Community Health Survey On Nutrition, Ulaina Tariq

Electronic Thesis and Dissertation Repository

Background: The added sugar intake of children and adolescents in Canada warrants more research due to its contribution to obesity, diabetes, and other chronic and mental health issues.

Objective: To assess the trends and correlates of added sugar intake in Canadians aged 6 to 17.

Methods: Data were provided by the Canadian Community Health Survey-Nutrition 2004 and 2015. Statistical analysis included multivariable regression and t-tests.

Results: In 2015, 35.66% of Canadians aged 6 to 17 met sugar intake guidelines. Compared to 2004, in 2015 intake of fruit and vegetables was higher, while sugar and caloric intake was lower. Sedentary activity, …


Knowledge, Attitudes And Behaviors Of Traditional Health Practices Among Cambodian Women (15-35 Years) Living In Massachusetts, Nan Dou Jul 2018

Knowledge, Attitudes And Behaviors Of Traditional Health Practices Among Cambodian Women (15-35 Years) Living In Massachusetts, Nan Dou

Masters Theses

Cambodian immigrants have become a large population group in the United States since late 1970s. Traditional heath practices and alcohol consumption during pregnancy and lactation have both been associated with risks of maternal and child health in previous research. However, these associations have never been investigated in the Cambodian immigrant population. The mechanism for the potential interaction is that the traditional health practice, the use of sraa t’nam, which is an alcohol concoction usually consumed during postpartum period, may increase risks for both mothers and children. Sraa t’nam is the traditional alcohol and drinking alcohol during pregnancy and while …


Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender May 2018

Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender

Student Theses 2015-Present

This paper aims to shed light on the dissonance caused by the superimposition of Dominant Human Systems on Natural Systems. I highlight the synthetic nature of Dominant Human Systems as egoic and linguistic phenomenon manufactured by a mere portion of the human population, which renders them inherently oppressive unto peoples and landscapes whose wisdom were barred from the design process. In pursuing a radical pragmatic approach to mending the simultaneous oppression and destruction of the human being and the earth, I highlight the necessity of minimizing entropic chaos caused by excess energy expenditure, an essential feature of systems that aim …


Clinical And Therapeutic Significance Of Obesity In Melanoma, Jennifer L. Mcquade Aug 2017

Clinical And Therapeutic Significance Of Obesity In Melanoma, Jennifer L. Mcquade

Dissertations & Theses (Open Access)

While the FDA approval of targeted and immune therapies in metastatic melanoma (MM) have dramatically improved outcomes in this disease, de novo and/or acquired resistance can limit the clinical benefit of these agents. The IGF-1/PI3K/AKT pathway has been implicated in resistance to both targeted and immune therapy. The IGF-1/PI3K/AKT pathway has also been shown to play a key role in the pathogenesis of obesity in other malignancies. To date, the impact of energy balance on clinical outcomes and therapeutic response in MM has not been studied. I hypothesized that energy balance would impact the molecular biology, behavior, and drug sensitivity …