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Full-Text Articles in Nutrition
Hydrophobic Probe Binding Of Β-Lactoglobulin In The Native And Molten Globule State Induced By High Pressure As Affected By Ph, Kio3 And N-Ethylmaleimide, Jian Yang, Joseph R. Powers, Stephanie Clark, A. Keith Dunker, Barry G. Swanson
Hydrophobic Probe Binding Of Β-Lactoglobulin In The Native And Molten Globule State Induced By High Pressure As Affected By Ph, Kio3 And N-Ethylmaleimide, Jian Yang, Joseph R. Powers, Stephanie Clark, A. Keith Dunker, Barry G. Swanson
Stephanie Clark
High hydrostatic pressure (HHP) at 500 MPa and 50 °C induces β-LG into the molten globule state. Retinol, cis-parinaric acid (CPA), and 1-anilino-naphthalene-8-sulfonate (ANS) fluorescence from pH 2.5 to 10.5 in the presence of the native and molten globule states of β-LG indicate that retinol binds to β-LG in the calyx, CPA at the surface hydrophobic site, and ANS in multiple hydrophobic sites. HHP treatment results in a decrease of β-LG affinity for retinol and CPA, suggesting conformational changes in the calyx and surface hydrophobic site of β-LG during HHP treatment. β-LG treated by HHP in the presence of N-ethylmaleimide …
Can Cranberry Supplementation Reduce Risks For Diabetes?, Belinda K. Chambers
Can Cranberry Supplementation Reduce Risks For Diabetes?, Belinda K. Chambers
Electronic Theses and Dissertations
Diabetes affects approximately 250 million people worldwide and health care costs related to diabetes equal approximately $98 billion each year. Aldose reductase has been shown to contribute to the side effects of diabetes including kidney disease, nerve disease, and retinopathy. Cranberries contain anthocyanins and other flavonoids that have been shown in vitro to inhibit the enzyme aldose reductase and to inhibit protein glycosylation. It is believed that daily cranberry supplementation could reduce side effects of diabetes. Twenty-seven adults with type 2 diabetes were recruited for this 12 week double-blind, placebo-controlled study. Fasting blood analysis was done at weeks 0, 6, …