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Full-Text Articles in Computational Neuroscience
Analysis Of Neuronal Sequences Using Pairwise Biases, Zachary Roth
Analysis Of Neuronal Sequences Using Pairwise Biases, Zachary Roth
Department of Mathematics: Dissertations, Theses, and Student Research
Sequences of neuronal activation have long been implicated in a variety of brain functions. In particular, these sequences have been tied to memory formation and spatial navigation in the hippocampus, a region of mammalian brains. Traditionally, neuronal sequences have been interpreted as noisy manifestations of neuronal templates (i.e., orderings), ignoring much richer structure contained in the sequences. This paper introduces a new tool for understanding neuronal sequences: the bias matrix. The bias matrix captures the probabilistic tendency of each neuron to fire before or after each other neuron. Despite considering only pairs of neurons, the bias matrix captures the best …