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Full-Text Articles in Computational Neuroscience
Role Of Neurogranin In The Regulation Of Calcium Binding To Calmodulin, Anuja Chandrasekar
Role Of Neurogranin In The Regulation Of Calcium Binding To Calmodulin, Anuja Chandrasekar
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Role of Neurogranin in the regulation of calcium binding to Calmodulin
Anuja Chandrasekar, B.S
Advisor: M. Neal Waxham, Ph.D
The overall goal of my project was to gain a quantitative understanding of how the interaction between two proteins neurogranin (RC3) and calmodulin (CaM) alters a fundamental property of CaM. CaM, has been extensively studied for more than four decades due to its seminal role in almost all biological functions as a calcium signal transducer. Calcium signals in cardiac and neuronal cells are exquisitely precise and enable activation of some processes while down-regulating others. CaM, with its four calcium binding sites, …