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Schizophrenia- Like Attentional Deficits Following Blockade Of Prefrontal Cortex Gaba(A) Receptors, Tracie A. Paine, Lauren E. Slipp, William A. Carlezon Jr.
Schizophrenia- Like Attentional Deficits Following Blockade Of Prefrontal Cortex Gaba(A) Receptors, Tracie A. Paine, Lauren E. Slipp, William A. Carlezon Jr.
Faculty & Staff Scholarship
Attentional deficits are a core symptom of schizophrenia. Post-mortem analyses of the brains of schizophrenics reveal consistent abnormalities in gamma-aminobutyric acid (GABA) interneurons indicative of reduced cortical GABA transmission, raising the possibility that this pathology contributes to attentional deficits. We examined whether blockade of prefrontal cortex (PFC) GABA(A) receptors with bicuculline (BMI) impairs attention in rats using the 5-choice serial reaction time task (5CSRTT). For comparison, we also examined whether administration of the GABA(A) receptor agonist muscimol (MUS) would improve attention. In parallel, we examined the effects of both manipulations on activity in an open field and on motivation using …