Neuroscience and Neurobiology Commons^™

Making The Invisible Visible: Mapping Chronic Pain Through Art, Caroline Young

Scripps Senior Theses

This Studio Art thesis explores how I use my art practice as a chronic pain healing process. It draws on the fundamentals of the neuroscience behind pain and the implications of this science for people with chronic pain. People with chronic pain often turn to alternative healing techniques in their search for relief; my own alternative healing approach comes from my art practice of “pain mapping."

The artistic healing process that I have developed takes inspiration from chronically ill artists such as Frida Kahlo and Anna Cowley Ford. The artistic mapping of my pain that I have developed primarily uses …

Does Seclusion Alter Amygdala Activity And Amygdala-Medial Prefrontal Cortex Connectivity Leading To Emotional Dysregulation In Children? A Case For Ending Seclusion And Restraint In Public Schools, Crystal Anyanwu

CMC Senior Theses

The use of seclusion as a disciplinary practice in schools has been cited as an effective way to mitigate a child’s behavior if they pose a threat of imminent danger to others or themselves and an effective means of helping a child regulate their emotions. However, research has shown that this practice has resulted in psychological harm (e.g. traumatic stress responses), physical injuries, and death to both staff applying these techniques and the children experiencing them. The effects of seclusion on the neurodevelopment of children remain widely unknown. Traumatic stress has been shown to increase the volume of the amygdala …

A Study Of Limited Bedding And Nesting On Maternal Behavior For Postpartum Depression, Emma Brezoczky

CMC Senior Theses

Postpartum depression (PPD) affects up to 20% of mothers in the US and can detrimentally affect both the mother and psychosocial development of the child (Pearlstein et al, 2009). So far, research on PPD is limited and the underlying neuropathology remains unclear. Low socioeconomic status is one risk factor that increases the risk of PPD tenfold (Goyal et al, 2010). The low resource limited bedding and nesting (LBN) paradigm used for rodents has the potential to model this risk factor. LBN has not previously been studied with PPD, but observations of disrupted maternal behaviors and depressive phenotypes makes it a …

Stress And The City: The Impacts Of City Living And Urbanization On Mental Health, Natalie Akins

Scripps Senior Theses

Urbanization is causing a demographic and cultural shift to the landscape of cities across the globe. Although urban living can be advantageous for both individual and societal growth, it can negatively affect mental health and wellbeing. Individuals living in urban environments have an increased risk for mental disorders like depression and schizophrenia. Certain challenges common in urban environments and associated with increased stress, may be causing the increase with mental illness. Chronic stress and the subsequent hyperactivation of the hypothalamic-pituitary-adrenal axis and sustained synthesis of glucocorticoids is detrimental to metabolic, endocrine, and immunologic processes. The overexposure to glucocorticoids can lead …

The Writing Brain: Writing As An Exercise Of Functional Network Optimization To Facilitate Psychologically Healing Effects, Isabelle Antolin

Scripps Senior Theses

James Baldwin wrote, “When you’re writing, you’re trying to find out something which you don’t know” (as cited in Plimpton 1989). Writers, like James Baldwin, have for a long time acknowledged that writing has some psychological effect. However, the neural basis of this effect has yet to be understood. Neuroimaging studies have examined writing as a creative process, identifying a predominantly left fronto-parieto-temporal network activation during writing tasks (including brainstorming, drafting, and revising). Importantly, one study examining poetry composition found that a generative phase of writing was associated with a significant anti-correlative activation pattern between the dorsal attention network (DAN) …

Not Coming Home: The Flaws In Skilled Nursing Facilities And Their Contribution To Cyclical Hospitalizations Of Post-Acute Patients, Kate Eisenbraun

Pitzer Senior Theses

This literature review will discuss the experience of patients within the US healthcare system, focusing on skilled nursing facilities (SNFs) and their contribution to cyclical hospitalizations. SNFs differ from nursing homes and other long-term care facilities by providing short-term, post-operational rehabilitation at a cost lower than what is offered at hospitals. Despite their critical role, SNFs often face fundamental issues, such as understaffing, underfunding, and staff burn-out, which result in lower quality patient care. This thesis argues that the issues faced by SNFs are a result of inconsistencies with state and federal staffing regulations, as well as inadequate insurance reimbursements. …

Energy As A Limiting Factor In Neuronal Seizure Control: A Mathematical Model, Sophia E. Epstein

CMC Senior Theses

The majority of seizures are self-limiting. Within a few minutes, the observed neuronal synchrony and deviant dynamics of a tonic-clonic or generalized seizure often terminate. However, a small epilesia partialis continua can occur for years. The mechanisms that regulate subcortical activity of neuronal firing and seizure control are poorly understood. Published studies, however, through PET scans, ketogenic treatments, and in vivo mouse experiments, observe hypermetabolism followed by metabolic suppression. These observations indicate that energy can play a key role in mediating seizure dynamics. In this research, I seek to explore this hypothesis and propose a mathematical framework to model how …