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Myosin Isoforms And Regulation Of Tonic And Phasic Contraction In Smooth Muscle, Qian Huang
Myosin Isoforms And Regulation Of Tonic And Phasic Contraction In Smooth Muscle, Qian Huang
Dissertations (1934 -)
The contractile properties of smooth muscle (SM) are broadly classified as tonic and phasic. Among the hypothesized underlying regulatory mechanisms for this difference is the different actomyosin ATPase kinetic properties of SM SMA/SMB myosin heavy chain (MHC) isoforms and the preferential expression of SMA and SMB MHC isoforms in tonic and phasic SM respectively. Thus, we hypothesized that SM SMA/B MHC expression determines tonic and phasic contractile patterns in SM.
To test the this hypothesis, the role of SMA and SMB MHC isoforms in tonic and phasic contractions was studied in phasic (longitudinal ileum and stomach circular antrum) and tonic …