Open Access. Powered by Scholars. Published by Universities.®

Neuroscience and Neurobiology Commons

Open Access. Powered by Scholars. Published by Universities.®

2012

Medical Neurobiology

Growth chart

Articles 1 - 1 of 1

Full-Text Articles in Neuroscience and Neurobiology

Smoothness Selection For Penalized Quantile Regression Splines, Philip T. Reiss, Lei Huang Apr 2012

Smoothness Selection For Penalized Quantile Regression Splines, Philip T. Reiss, Lei Huang

Philip T. Reiss

Modern data-rich analyses may call for fitting a large number of nonparametric quantile regressions. For example, growth charts may be constructed for each of a collection of variables, to identify those for which individuals with a disorder tend to fall in the tails of their age-specific distribution; such variables might serve as developmental biomarkers. When such analyses are carried out by penalized spline smoothing, reliable automatic selection of the smoothing parameter is particularly important. We show that two popular methods for smoothness selection may tend to overfit when estimating extreme quantiles as a smooth function of a predictor such as …