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Full-Text Articles in Neuroscience and Neurobiology
Maternal Separation Affects Dopamine Transporter Function In The Spontaneously Hypertensive Rat: An In Vivo Electrochemical Study, Jacqueline S. Womersley, Jennifer H. Hsieh, Lauriston A. Kellaway, Greg A. Gerhardt, Vivienne A. Russell
Maternal Separation Affects Dopamine Transporter Function In The Spontaneously Hypertensive Rat: An In Vivo Electrochemical Study, Jacqueline S. Womersley, Jennifer H. Hsieh, Lauriston A. Kellaway, Greg A. Gerhardt, Vivienne A. Russell
Neuroscience Faculty Publications
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterised by symptoms of inattention, impulsivity and hyperactivity. The spontaneously hypertensive rat (SHR) is a well-characterised model of this disorder and has been shown to exhibit dopamine dysregulation, one of the hypothesised causes of ADHD. Since stress experienced in the early stages of life can have long-lasting effects on behaviour, it was considered that early life stress may alter development of the dopaminergic system and thereby contribute to the behavioural characteristics of SHR. It was hypothesized that maternal separation would alter dopamine regulation by the transporter (DAT) in ways that distinguish SHR …
Adaptive Significance Of Natural Variations In Maternal Care In Rats: A Translational Perspective, Annaliese K. Beery, Darlene D. Francis
Adaptive Significance Of Natural Variations In Maternal Care In Rats: A Translational Perspective, Annaliese K. Beery, Darlene D. Francis
Neuroscience: Faculty Publications
A wealth of data from the last fifty years documents the potency of early life experiences including maternal care on developing offspring. A majority of this research has focused on the developing stress axis and stress-sensitive behaviors in hopes of identifying factors impacting resilience and risk-sensitivity. The power of early life experience to shape later development is profound and has the potential to increase fitness of individuals for their environments. Current findings in a rat maternal care paradigm highlight the complex and dynamic relation between early experiences and a variety of outcomes. In this review we propose adaptive hypotheses for …
Gender Differences In The Processing Of Acute And Repeated Stress, Jaidee Zavala
Gender Differences In The Processing Of Acute And Repeated Stress, Jaidee Zavala
Open Access Theses & Dissertations
Chronic stress is implicated in the pathogenesis of a variety of diseases, including affective, immune and cardiovascular disorders, which are differentially experienced by men and women. Corticotropin-releasing factor (CRF), arginine vasopressin (AVP), and glucocorticoid receptor (GR) are the major regulators of the stress response and are widely expressed in the paraventricular nucleus of the hypothalamus (PVH), where adaptive responses to stress are generated. Adult male and female rats were subjected to single (acute) or 14 consecutive daily (repeated) 30 min restraint sessions, or maintained as unstressed controls. Rats were perfused after their final restraint, and their brain tissues sectioned and …