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Full-Text Articles in Neuroscience and Neurobiology
Neuroprotective Effects Of Anthocyanins On Neuronal Death Induced By Inhibition Of Bcl-2 And Oxidative Stress, Natalie A. Kelsey
Neuroprotective Effects Of Anthocyanins On Neuronal Death Induced By Inhibition Of Bcl-2 And Oxidative Stress, Natalie A. Kelsey
Electronic Theses and Dissertations
Neurodegenerative diseases such as Parkinson’s and amyotrophic lateral sclerosis have devastating consequences to the afflicted patients. A major cellular pathophysiology underlying these diseases is mitochondrial oxidative stress (MOS) leading to neuronal death. Here, we investigated the neuroprotective effects of a novel class of nutraceuticals, anthocyanins, against MOS-induced death in primary cultures of rat cerebellar granule neurons (CGNs). Anthocyanins are natural antioxidants whose neuroprotective potential has yet to be examined in detail. Kuromanin and callistephin are anthocyanins derived from black rice and strawberries, respectively. Glutathione (GSH)-sensitive MOS and intrinsic apoptosis were induced in CGNs by the Bcl-2 inhibitor, HA14-1. Callistephin and …
Overexpression Of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress And Activates The Intrinsic Apoptosis Pathway, Matthew G. Bartley
Overexpression Of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress And Activates The Intrinsic Apoptosis Pathway, Matthew G. Bartley
Electronic Theses and Dissertations
Down syndrome (DS) is the most common genetic form of cognitive disability and is caused by trisomy of chromosome 21. Within chromosome 21 is the gene, amyloid precursor protein (APP). Proteolysis of APP into toxic and aggregate-prone, beta-amyloid fragments underlies the pathophysiology of Alzheimer's disease (AD). Individuals with DS develop the neuropathology that can be diagnosed as AD; however, the role of APP overexpression in this comorbidity is presently unclear. Here, we elucidated the mechanism of cell death induced by overexpression of wild type APP. Chinese hamster ovary cells transfected with a DsRed-APP fusion construct displayed caspase-3 activation and nuclear …