Neuroscience and Neurobiology Commons^™

Comparison Of The Effects Of Saporin-Igg Injections Into The Nucleus Basalis Magnocellularis And Medial Septal Area Of Male Rat As Assessed By The Morris Water Maze Task, Alexander R. V. Mccampbell '95

Honors Projects

Alzheimer's disease currently afflicts approximately 4 million people in the United States, with 100,000 new cases being reported each year. As post mortem examination of AD patientsI brains has revealed a significant decrease in the number of cholinergic neurons, one approach we have taken is to look at the correlation between the depletion of certain cholinergic markers in animals and the resulting behavioral deficits. Two regions of specific interest are the medial septal area (MSA) and the nucleus basalis magnocellularis (NBM). These regions are important because they are the major source of cholinergic neurons in the brain, they are selectively …