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Full-Text Articles in Neuroscience and Neurobiology
Characterization Of Caenorhabditis Elegans F07a5.4, Human Ortholog Of Olfactomedin 1, Sade K. Thomas, Karunambigai Kalichamy, Martin Hudson
Characterization Of Caenorhabditis Elegans F07a5.4, Human Ortholog Of Olfactomedin 1, Sade K. Thomas, Karunambigai Kalichamy, Martin Hudson
Symposium of Student Scholars
Accurate control of nervous system development is critical for normal brain patterning, and defects in this process can lead to neurological disorders such as schizophrenia and Autism Spectrum Disorder. The transcription factor neurogenin is necessary for the development of neural subtypes and is deeply conserved across species. However, the transcriptional targets of neurogenin are poorly understood, creating an imperative for further study. We have used the nematode Caenorhabditis elegans as a model to better understand ngn-1/neurogenin function. Previous work from our lab revealed that ngn-1 plays a role in nerve ring architecture, and neural cell fate specification. In addition, …