Neuroscience and Neurobiology Commons^™

Quantifying Cognitive Function In Concussed Athletes Before And After Acute Exercise Using A Choice Reaction Time Task, Stephanie A. Ramautar M.Sc., Michael E. Cinelli Ph.D.

Theses and Dissertations (Comprehensive)

Following a concussion, cognitive deficits have been shown to last longer than symptom resolution. Currently clinicians rely heavily on symptom emergence following the fundamental exercises of the return to play (RTP) protocol, which may leave athletes at risk of returning to play too early if cognitive deficits have not been detected. The purpose of this study was to assess the effects of exercise on choice reaction time (CRT) both at rest and following an acute exercise in 3 populations: non-concussed (NC), recently concussed (RC), and post-concussion syndrome (PCS) individuals. A CRT task in the form of an iPad application measured …

Characterization Of The Transporter Protein Sodium-Potassium Adenosine Triphosphatase In The Myelin Membrane, Dara E C Schaefer

Theses and Dissertations (Comprehensive)

Sodium-potassium adenosine triphosphatase (Na⁺/K⁺-ATPase) is an integral membrane protein with known involvement in the maintenance of resting membrane potentials, nutrient uptake, cellular signal transduction, and cell-cell adhesion. The functional enzyme contains a catalytic alpha subunit and a glycosylated beta subunit, of which three isoforms of each are known to exist in the central nervous system (CNS). Altered expression and/or activity of Na⁺/K⁺-ATPase subunit isoforms has been previously implicated in the pathophysiology of several neurological disorders. This study characterized Na⁺/K⁺-ATPase expression and distribution in the myelin membrane, identified its …

A Bittersweet Investigation Of Availability And Nutritive Value As Determinants Of Volitional Sucrose Consumption, Milan D. Valyear

Theses and Dissertations (Comprehensive)

Rats given ~24 h access to a 4% sucrose solution every 3^rd day (E3DA) consume about 100 g more solution than rats with continuous, everyday access (EDA). Under the same EDA-E3DA conditions rats will consume similar amounts of a more concentrated 8 or 16% sucrose solutions (Eikelboom, Hewitt, & Adams, Unpublished). It maybe that with these more concentrated solutions rats hit a satiety limit that prevents a difference between EDA and E3DA consumption from being evident. Experiment 1 was conducted to investigate the effect of adding quinine to 4% and 8% sucrose solutions with the intention of reducing consumption …

Recovery From Acute Toluene Intoxication Is Facilitated By The Nmda Receptor Co-Agonist D-Serine, But Not The Gabaa Receptor Antagonist Picrotoxin, Susan R. Samuel-Herter

Theses and Dissertations (Comprehensive)

Toluene is a volatile solvent found in many household products and when intentionally inhaled results in intoxication. In rats, acute inhalation of toluene results in sedation and neurological impairments, with marked increases in ambulation and vertical behaviour during the recovery period. Previous in vitro research has shown that toluene may exert its effects by inhibiting NMDA receptors, and / or by activating GABA_A receptors. To test whether modulation of these receptors are also implicated in the changes in motor behaviour and neurological impairments resulting from toluene vapour inhalation, rats were injected with the NMDA receptor co-agonist D-serine (1000 mg/kg …

Time, Perspectives, Verbs, And Imagining Events, Jeffrey P. Hong

Theses and Dissertations (Comprehensive)

During the processing of verbs, readers form internal representations of the events described by those verbs. Two key elements in the construction of event representations are temporal information, given by the verbs that describe the represented events, and the visual perspective from which the events are represented. The current study is composed of two experiments aimed at examining the roles these two factors play in event representation. Specifically, the study aimed to determine how temporal information and visual perspective are represented during event imagination.

Experiment 1 investigated the role of temporal information associated with verbs, given by grammatical aspect (GA) …