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Divalent Metal Cation Entry And Cytotoxicity In Jurkat T Cells: Role Of Trpm7 Channels, Alayna N. Mellott
Divalent Metal Cation Entry And Cytotoxicity In Jurkat T Cells: Role Of Trpm7 Channels, Alayna N. Mellott
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Humans are exposed daily to a variety of metals that can be harmful to our immune system. Although certain divalent metal cations are essential for numerous cellular functions and are critical trace elements in humans, the uptake mechanisms of these ions remain mostly unknown. Transient receptor potential melastatin 7 (TRPM7), which is expressed in a variety of human cell types, including lymphocytes and macrophages, conducts many divalent metal cations. TRPM7 channels are largely inactive under normal physiological conditions due to cytoplasmic magnesium acting as a channel inhibitor. Magnesium is a cofactor for many biochemical reactions. Low serum levels of magnesium, …
Trpm7 Channels As A Bioassay Of Internal And External Mg2+, Charles T. Luu
Trpm7 Channels As A Bioassay Of Internal And External Mg2+, Charles T. Luu
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Magnesium is an important divalent metal cation that is involved in numerous cellular functions. The details of cellular Mg2+ regulation, homeostasis and transport remain unclear. Magnesium transporter protein (MagT1) is a Mg2+ transporter and deficiency of this protein has been reported to lead to impaired Mg2+ influx and a decreased cytoplasmic [Mg2+]. Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed membrane protein containing a channel pore and a C-terminal alpha-type serine/threonine protein kinase domain. Importantly, TRPM7 channel is believed to conduct both Mg2+ and Ca2+. In the present study, we investigated if TRPM7 can be used as a …