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Full-Text Articles in Neuroscience and Neurobiology
Inter-Subject Correlation Using Movie-Driven Fmri In Drug-Resistant Epilepsy, Hana H. Abbas
Inter-Subject Correlation Using Movie-Driven Fmri In Drug-Resistant Epilepsy, Hana H. Abbas
Electronic Thesis and Dissertation Repository
Treating drug-resistant epilepsy with surgery requires the localization of the epileptic focus. We explored the potential for movie-driven functional magnetic resonance imaging (fMRI) to act as a sensitive, non-invasive, and cost-effective tool to identify functionally disturbed networks. We assessed neural synchronization (inter-subject correlation; ISC) between presurgical epilepsy patients (n = 18) and healthy controls (n = 24) as they watched a suspenseful movie clip in the scanner. To optimize denoising, we compared ISC values with and without an automated Independent Components Analysis-based denoising step (ICA-AROMA). We found that denoising with ICA-AROMA elicited augmented correlation values, supporting its use …
Modulation Of Gabaa Receptor By Neurosteroids And Protein Kinases In Health And Disease, Jaymin Jeong
Modulation Of Gabaa Receptor By Neurosteroids And Protein Kinases In Health And Disease, Jaymin Jeong
Electronic Thesis and Dissertation Repository
γ-aminobutyric acid type A receptors (GABAA receptors) underlie the majority of inhibitory synaptic transmission in the brain. Modulation of GABAergic activity occurs in development and normal physiological functioning of the brain, and changes to GABAergic function has been implicated in numerous neurological disorders including epilepsy. Neurosteroids, metabolites of steroid hormones, and kinases are known to modulate GABAA receptor mediated currents in health and disease. This thesis aims to investigate the effects of kinases and neurosteroids on modulating GABAA receptor-mediated currents in cortical pyramidal cells and their effects on the piriform cortex (PCtx) circuit in naïve rats and …