Neuroscience and Neurobiology Commons^™

Ethanol Exposure During Synaptogenesis In A Mouse Model Of Fetal Alcohol Spectrum Disorders: Acute And Long-Term Effects On Gene Expression And Behaviour, Morgan L. Kleiber

Electronic Thesis and Dissertation Repository

Alcohol is a neuroactive molecule that is able to exert variable and often detrimental effects on the developing brain, resulting in a broad range of physiological, behavioural, and cognitive phenotypes that characterize ‘fetal alcohol spectrum disorders’ (FASD). Factors affecting the manifestation of these phenotypes include alcohol dosage, timing of exposure, and pattern of maternal alcohol consumption; however, the biological processes that are vulnerable to ethanol at any given neurodevelopmental stage are unclear, as is how their disruption results in the emergence of specific pathological phenotypes later in life.

The research included in this thesis utilizes a C57BL/6J (B6) mouse model …

The Characterization Of The Fibroblast Growth Factor Receptor Substrate 3 And Its Role In Regulating Microtubule Dynamics And Molecular Transport In The Brain, Sarah J. Gamble

Electronic Thesis and Dissertation Repository

The neuronal cytoskeleton is responsible for governing dynamics such as neurite extension and cortex development. In particular, microtubules (MTs) and their associated proteins, and molecular motors, have been shown to be critical in many neuronal processes such as intracellular molecular transport and neuron differentiation. The fibroblast growth factors (FGFs) act as powerful morphogens that have been shown to play a role in regulating cortical development. FGFs activate receptor tyrosine kinases, of which fibroblast growth factor receptor substrate 3(FRS3) has been shown to interact with, to mediate downstream signaling cascades (regulating cell proliferation and differentiation). In addition to FRS3’s role in …