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Neuroscience and Neurobiology Commons™
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Articles 1 - 6 of 6
Full-Text Articles in Neuroscience and Neurobiology
Perceiving Oldness In Parietal Cortex: Fmri Characterization Of A Parietal Memory Network, Adrian Gilmore
Perceiving Oldness In Parietal Cortex: Fmri Characterization Of A Parietal Memory Network, Adrian Gilmore
Arts & Sciences Electronic Theses and Dissertations
The manner in which the human brain recognizes certain stimuli as novel or familiar is a matter of ongoing investigation. The overarching goal of this dissertation is to improve our understanding of how this may be accomplished. More specifically, work contained herein focuses on a recently described "parietal memory network" (PMN; Gilmore et al., 2015) that shows opposite patterns of activity when perceiving novel or familiar stimuli: deactivating in response to novelty, and activating in response to familiarity. Critically, our understanding of this network is based on explicit memory tasks, in which subjects are deliberately instructed to learn or remember …
Development And Investigation Of Sparse Co-Adaptive Algorithms In Ecog Based Closed-Loop Brain Computer Interface, Piyush Karande
Development And Investigation Of Sparse Co-Adaptive Algorithms In Ecog Based Closed-Loop Brain Computer Interface, Piyush Karande
McKelvey School of Engineering Theses & Dissertations
Electrocorticography (ECoG) has gained a lot of momentum and has become a serious contender as a recording modality for the implementation of Brain-Computer Interface (BCI) systems in the last few years. ECoG signals provide the right balance between minimal invasiveness and robust spectral information to accomplish a BCI task. However, all the BCI studies until now have used signals recorded from a large number of implanted electrodes and a larger number of spectral features. The recording and processing of these signals uses a lot of electrical power and thus hinders its use outside the research setting. To translate this research …
The Molecular And Cellular Basis For Cold Sensation, Daniel Brenner
The Molecular And Cellular Basis For Cold Sensation, Daniel Brenner
Arts & Sciences Electronic Theses and Dissertations
The ability to sense changes in temperature is crucial to surviving harsh environments. Over the last decade several ion channels that have been proposed to be cold sensitive have been identified, most notably TRPM8 and TRPA1. Although these molecules have been extensively studied in vitro, their exact roles in cold sensation in vivo are still debated. This uncertainty is in large part due to problems with the standard methods of testing cold sensitivity in vivo, which often rely on subjective measures of cold responsiveness. Experiments using these subjective measures have been repeated by different groups and have yielded conflicting results, …
Superoxide Dismutase 1: Novel Insights On Disease Models And Tissue Specificity In Amyotrophic Lateral Sclerosis, Matthew James Crisp
Superoxide Dismutase 1: Novel Insights On Disease Models And Tissue Specificity In Amyotrophic Lateral Sclerosis, Matthew James Crisp
Arts & Sciences Electronic Theses and Dissertations
Mutations in superoxide dismutase 1 (SOD1) are known to cause dominantly-inherited amyotrophic lateral sclerosis (ALS), a rapidly-fatal adult-onset neurodegenerative disorder defined by motor neuron loss and progressive paralysis. In the past twenty years, research into the disorder has been driven by the creation of numerous transgenic animal models that have yielded multiple theories on the pathogenesis of the disease. Patients and animal models with SOD1 mutations express the defective protein in every cell, yet the disease only affects tissues in the neuromuscular axis. In this dissertation, I present original work exploring two aspects of SOD1 ALS. The first details the …
The Murine Accessory Olfactory Bulb As A Model Chemosensory System: Experimental And Computational Analysis Of Chemosensory Representations, Gary Francis Hammen
The Murine Accessory Olfactory Bulb As A Model Chemosensory System: Experimental And Computational Analysis Of Chemosensory Representations, Gary Francis Hammen
Arts & Sciences Electronic Theses and Dissertations
A common challenge across sensory processing modalities is forming meaningful associations between the neural responses and the outside world. These neural representations of the world must then be integrated across different sensory systems contributing to each individuals perceptual experience. While there has been considerable study of sensory representations in the visual system of humans and multiple model organisms, other sensory domains, including olfaction, are less well understood. In this thesis, I set out to better understand the sensory representations of the mouse accessory olfactory system (AOS), a part of the olfactory system. The mouse AOS, our model chemosensory system, comprises …
Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou
Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou
McKelvey School of Engineering Theses & Dissertations
Stroke is the most common cause of long-term severe disability and the motor system that is most commonly affected in stroke. One of the mechanisms that underlies recovery of motor deficits is reorganization or remapping of functional representations around the motor cortex. This mechanism has been shown in monkeys, but results in human subjects have been variable. In this thesis, I used a database that includes longitudinal behavioral and multimodal imaging data in both stroke patients and healthy controls for two research projects. Firstly, I improved an automatic lesion segmentation method to aid in the identification of the location and …