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Neuroscience and Neurobiology Commons™

Open Access. Powered by Scholars. Published by Universities.®

University of Wisconsin Milwaukee

2015

Articles 1 - 8 of 8

Full-Text Articles in Neuroscience and Neurobiology

Functionally Distinct Pools Of Calcineurin Contribute To Depotentiation-Like Synaptic Changes In The Lateral Amygdala During Auditory Fear Extinction, Elena Kay Rotondo Dec 2015

Functionally Distinct Pools Of Calcineurin Contribute To Depotentiation-Like Synaptic Changes In The Lateral Amygdala During Auditory Fear Extinction, Elena Kay Rotondo

Theses and Dissertations

Until recently, auditory fear extinction was not thought to modify substrates involved in the storage of the original auditory fear memory. Evidence now suggests that extinction results in the reversal of the fear conditioning-induced potentiation of thalamic inputs to the lateral amygdala. However, little is known about the molecular mechanisms that support this depotentiation of synaptic strength. Here we present behavioral and molecular evidence in support of the contribution of two distinct pools of the protein phosphatase calcineurin to depotentiation-like changes in lateral amygdala AMPA receptor trafficking during auditory fear extinction. Calcineurin protein that exists prior to the onset of …

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Neural Mechanisms Supporting Differential Auditory Fear Conditioning, Nicole Christine Ferrara Dec 2015

Neural Mechanisms Supporting Differential Auditory Fear Conditioning, Nicole Christine Ferrara

Theses and Dissertations

Pavlovian fear conditioning provides an ideal way to study memory formation, retention, and updating. Plasticity in the auditory thalamus is required during the acquisition and consolidation of a fear memory when a tone signals a foot shock. The medial geniculate nucleus (MgN) of the auditory thalamus sends projections to the amygdala and auditory cortex and is functionally divided into two different regions, the medial division (MGm) and the ventral division (MGv). Traditionally, these divisions are thought to relay auditory information to the amygdala during fear-related associative learning. However, recent research has suggested a more complex role for the MgN when …

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Effects Of Global Dna Methylation Changes On Neurobehavior In Zebrafish, Matthew Christopher Pickens Dec 2015

Effects Of Global Dna Methylation Changes On Neurobehavior In Zebrafish, Matthew Christopher Pickens

Theses and Dissertations

A number of environmental neurotoxicants modulate DNA methylation, but its influence on neurobehavior remains unclear. The laboratory has established that low-level developmental methylmercury exposure induces neurobehavioral deficits; the current results demonstrate that it also induces global DNA hypomethylation. DNA methyltransferase 1-mutant zebrafish (exhibit ~70% reduction in enzymatic activity) were used to assess the role of DNA hypomethylation on behavior. Several neurobehavioral assays including the C-start escape, circadian rhythm, basic locomotion and visual-motor response (VMR) were also performed. There was a significant difference in VMR between the wild type and mutant animals. Other behavior assays revealed no significant difference, primarily due …

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The Effects Of 830nm Light On Inflammation In Retinitis Pigmentosa, Krystal Marie Bach Aug 2015

The Effects Of 830nm Light On Inflammation In Retinitis Pigmentosa, Krystal Marie Bach

Theses and Dissertations

Purpose: Retinitis Pigmentosa (RP) is an inherited retinal degenerative disease and the most common cause of blindness in developed countries, affecting approximately 1 in 4,000 people. RP is characterized by photoreceptor cell death and recent studies suggest that chronic inflammation may play a key role in the pathogenesis of RP. Currently, there are no known treatments or preventive measures to delay or halt the loss of photoreceptor cells. Photobiomodulation (PBM) by light in the far-red or near-infrared (NIR) range of the light spectrum has been documented to help promote cell survival and reduce inflammation in several disease states. Recent studies …

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Relationship Between Learning-Related Synaptic And Intrinsic Plasticity Within Lateral Amygdala, Megha Sehgal Aug 2015

Relationship Between Learning-Related Synaptic And Intrinsic Plasticity Within Lateral Amygdala, Megha Sehgal

Theses and Dissertations

A central question in neuroscience is to determine the mechanisms that govern formation, storage and modulation of memories. Determining these mechanisms would allow us to facilitate new memory formation as in the case of aging-related cognitive decline or weaken preexisting pathological memories such as traumatic memories and cue-induced drug craving. Pharmacological and genetic manipulation of intrinsic neuronal excitability has been demonstrated to impact the strength of memory formation, allocation of memories, and modulation of memories through retrieval and reconsolidation-dependent processes. In addition to experimental manipulations of intrinsic excitability, intrinsic plasticity, a change in neuronal intrinsic excitability, can be brought about …

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Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis May 2015

Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis

Theses and Dissertations

The consolidation of fear memories is known to depend on a number of critical cellular processes including de novo protein synthesis and 26S proteasome-dependent protein degradation following auditory fear conditioning (Jarome et al., 2011; Kwapis et al., 2011). Early work has suggested that protein degradation, mediated by the ubiquitin proteasome system (UPS), may regulate the requirement for de novo protein synthesis during memory consolidation (Jarome & Helmstetter, 2014). However, the precise way in which the UPS is able to regulate mechanisms of protein synthesis remain unclear. In the present set of experiments, we investigated the role of the protein phosphatase …

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The Effects Of Antibodies In Disease Progression Of Mog-Induced Experimental Autoimmune Encephalomyelitis, Melissa Marie Riter May 2015

The Effects Of Antibodies In Disease Progression Of Mog-Induced Experimental Autoimmune Encephalomyelitis, Melissa Marie Riter

Theses and Dissertations

Abstract: Multiple sclerosis (MS) is an auto-inflammatory disease of the central nervous system (CNS), affecting over 400,000 people in the US. MS is primarily studied in the animal model experimental autoimmune encephalomyelitis (EAE). MS is a T cell mediated disease but there is mounting evidence for a role for B cells in MS. Previous studies have established that rMOG Induction depends on the presence of B cells, while induction using the MOG peptide covering amino acids 35-55 does not require B cells to cause disease. When plasma from the rMOG and MOG35-55 immunized WT mice was analyzed by ELISA there …

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Maximizing The Effects Of Passive Training On Visuomotor Adaptation By Incorporating Other Motor Learning Strategies, Yuming Lei May 2015

Maximizing The Effects Of Passive Training On Visuomotor Adaptation By Incorporating Other Motor Learning Strategies, Yuming Lei

Theses and Dissertations

Passive training has been shown to be an effective rehabilitation approach for stroke survivors, especially for those who suffer from severe control loss or complete paralysis. However, the effectiveness of the treatments that utilize passive assist training is still low. The goal of this dissertation was to develop a training condition that can maximize the effects of passive training on motor learning by combining its effect with other motor learning strategies. To achieve this goal, two specific aims were pursued: one aim was to determine the effects of passive training on learning a visuomotor adaptation task; and the other aim …

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