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Macro- And Mesoscale Analysis Of Connections Between The Cingulate Region And The Lateral Hypothalamic Area: Tracer Co-Injection And Chemoarchitectural Studies In The Adult Male Rat, Kenichiro Negishi

Open Access Theses & Dissertations

Hypothalamic research since the middle of the 20th century shaped the view that the lateral hypothalamic area (LHA) has a central role in controlling appetitive drives. The LHA is anatomically positioned to receive converging axonal inputs which relay information about the body's metabolic state as well as descending projections from the cerebral hemispheres, which encode cognitive and emotional states that influence feeding. Cerebral inputs are capable of initiating feeding despite the presence of competing satiety signals. Recent work has shown that medial prefrontal cortical areas can drive feeding in sated animals, possibly by engaging hypothalamic hypocretin/orexin (H/O)-expressing neurons, which are …