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Insular Cortex Lesions And Morphine-Induced Suppression Of Conditioned Stimulus Intake In The Rat, Christopher T. Roman, Steve Reilly
Insular Cortex Lesions And Morphine-Induced Suppression Of Conditioned Stimulus Intake In The Rat, Christopher T. Roman, Steve Reilly
Christopher Roman
The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.
Morphine-Induced Suppression Of Conditioned Stimulus Intake: Effects Of Stimulus Type And Insular Cortex Lesions, Jian-You Lin, Christopher T. Roman, Steve Reilly
Morphine-Induced Suppression Of Conditioned Stimulus Intake: Effects Of Stimulus Type And Insular Cortex Lesions, Jian-You Lin, Christopher T. Roman, Steve Reilly
Christopher Roman
Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived innate reward value. Two major findings emerged from this study. First, morphine suppressed intake of an aqueous odor as well as each taste stimulus in neurologically intact rats. Second, IC lesions disrupted morphine-induced suppression of the taste stimuli but not the aqueous odor cue. These results indicate that the perceived innate reward value of …
Basolateral Amygdala And Morphine-Induced Taste Avoidance In The Rat, Jamie Lovaglio, Jian-You Lin, Christopher T. Roman, Steve Reilly
Basolateral Amygdala And Morphine-Induced Taste Avoidance In The Rat, Jamie Lovaglio, Jian-You Lin, Christopher T. Roman, Steve Reilly
Christopher Roman
The present experiment examined the influence of excitotoxic lesions of the basolateral amygdala (BLA) on morphine-induced saccharin avoidance. Neurologically intact subjects rapidly learned to avoid drinking the taste conditioned stimulus (CS), an effect that was sustained throughout the experiment. Although the BLA-lesioned (BLAX) rats showed CS avoidance over the first few trials, the effect was not sustained. That is, by the end of the experiment, the BLAX rats were drinking the same amount of saccharin after seven saccharin-morphine trials as they did on the first trial (i.e., prior to the morphine injections). Potential interpretations of the results are discussed including …