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Full-Text Articles in Neuroscience and Neurobiology
Regardless Of Genotype, Offspring Of Vip-Deficient Female Mice Exhibit Developmental Delays And Deficits In Social Behavior., Hewlet Mcfarlane
Regardless Of Genotype, Offspring Of Vip-Deficient Female Mice Exhibit Developmental Delays And Deficits In Social Behavior., Hewlet Mcfarlane
Hewlet McFarlane
Pharmacological studies indicate that vasoactive intestinal peptide (VIP) may be necessary for normal embryonic development in the mouse. For example, VIP antagonist treatment before embryonic day 11 resulted in developmental delays, growth restriction, modified adult brain chemistry and reduced social behavior. Here, developmental milestones, growth, and social behaviors of neonates of VIP-deficient mothers (VIP +/-) mated to VIP +/- males were compared with the offspring of wild type mothers (VIP +/+) mated to VIP +/+ and +/- males, to assess the contributions of both maternal and offspring VIP genotype. Regardless of their own genotype, all offsprings of VIP-deficient mothers exhibited …
Social Approach Behaviors Are Similar On Conventional Versus Reverse Lighting Cycles, And In Replications Across Cohorts, In Btbr T+ Tf/J, C57bl/6j, And Vasopressin Receptor 1b Mutant Mice, Hewlet G. Mcfarlane, Mu Yang, Maria Luisa Scattoni, Vladimir Zhodzishsky, Thomas Chen, Heather Caldwell, W. Scott Young, Jacqueline N. Crawley
Social Approach Behaviors Are Similar On Conventional Versus Reverse Lighting Cycles, And In Replications Across Cohorts, In Btbr T+ Tf/J, C57bl/6j, And Vasopressin Receptor 1b Mutant Mice, Hewlet G. Mcfarlane, Mu Yang, Maria Luisa Scattoni, Vladimir Zhodzishsky, Thomas Chen, Heather Caldwell, W. Scott Young, Jacqueline N. Crawley
Hewlet McFarlane
Mice are a nocturnal species, whose social behaviors occur primarily during the dark phase of the circadian cycle. However, laboratory rodents are frequently tested during their light phase, for practical reasons. We investigated the question of whether light phase testing presents a methodological pitfall for investigating mouse social approach behaviors. Three lines of mice were systematically compared. One cohort of each line was raised in a conventional lighting schedule and tested during the light phase, under white light illumination; another cohort was raised in a reverse lighting schedule and tested during their dark phase, under dim red light. Male C57BL/6J …
Reduced Ultrasonic Vocalizations In Vasopressin 1b Knockout Mice., Hewlet Mcfarlane
Reduced Ultrasonic Vocalizations In Vasopressin 1b Knockout Mice., Hewlet Mcfarlane
Hewlet McFarlane
The neuropeptides oxytocin and vasopressin have been implicated in rodent social and affiliative behaviors, including social bonding, parental care, social recognition, social memory, vocalizations, territoriality, and aggression, as well as components of human social behaviors and the etiology of autism. Previous investigations of mice with various manipulations of the oxytocin and vasopressin systems reported unusual levels of ultrasonic vocalizations in social settings. We employed a vasopressin 1b receptor (Avpr1b) knockout mouse to evaluate the role of the vasopressin 1b receptor subtype in the emission of ultrasonic vocalizations in adult and infant mice. Avpr1b null mutant female mice emitted fewer ultrasonic …
M100,907, A Selective 5-Ht(2a) Antagonist, Attenuates Dopamine Release In The Rat Medial Prefrontal Cortex., Hewlet Mcfarlane
M100,907, A Selective 5-Ht(2a) Antagonist, Attenuates Dopamine Release In The Rat Medial Prefrontal Cortex., Hewlet Mcfarlane
Hewlet McFarlane
Previous research has suggested that serotonin 5-HT(2A) receptors modulate the functioning of the mesocortical dopamine (DA) pathway. However, the specific role of 5-HT(2A) receptors localized within the medial prefrontal cortex (mPFC) is not known. The present study employed in vivo microdialysis to examine the role of this receptor in the modulation of basal and K(+)-stimulated (Ca(2+)-dependent) DA release. The selective 5-HT(2A) antagonist M100,907 was infused directly into the mPFC of conscious rats. This resulted in a concentration-dependent blockade of K(+)-stimulated DA release. Intracortical application of M100,907 also blocked increases in DA release produced by the systemic administration of the 5-HT(2A/2C) …
Social Habituation And Dishabituation In Cd-1 Mice Treated With The Norepinephrine Neurotoxin N-(2-Chloroethyl)-N-Ethyl-2-Bromobenzylamine (Dsp-4), Hewlet Mcfarlane
Social Habituation And Dishabituation In Cd-1 Mice Treated With The Norepinephrine Neurotoxin N-(2-Chloroethyl)-N-Ethyl-2-Bromobenzylamine (Dsp-4), Hewlet Mcfarlane
Hewlet McFarlane
Male CD-1 mice between postnatal days 60 and 90 were injected intraperitoneally (i.p) with either water vehicle (controls) or 50$\mu$g/g of the norepinephrine neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4). They were tested 3 to 6 days later on the odors of adult males in a four-trial habituation/dishabituation paradigm. There were four groups: group CSS were water injected and exposed to the same male on all four trials; group CSN were water injected and exposed to the same male on the first three trials and a novel one on the fourth; group DSN were DSP-4 treated and exposed the same male on the first …
Autism-Like Behavioral Phenotypes In Btbr Ttf/J Mice. Genes, Hewlet Mcfarlane
Autism-Like Behavioral Phenotypes In Btbr Ttf/J Mice. Genes, Hewlet Mcfarlane
Hewlet McFarlane
No abstract provided.