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Effects Of Insular Cortex Lesions On Conditioned Taste Aversion And Latent Inhibition In The Rat, Christopher T. Roman, Steve Reilly
Effects Of Insular Cortex Lesions On Conditioned Taste Aversion And Latent Inhibition In The Rat, Christopher T. Roman, Steve Reilly
Christopher Roman
The present study tested the hypothesis that lesions of the insular cortex of the rat retard the acquisition of conditioned taste aversions (CTAs) because of an impairment in the detection of the novelty of taste stimuli. Demonstrating the expected latent inhibition effect, nonlesioned control subjects acquired CTAs more rapidly when the conditioned stimulus (0.15% sodium saccharin) was novel rather than familiar (achieved by pre-exposure to the to-be-conditioned taste cue). However, rats with insular cortex lesions acquired taste aversions at the same slow rate regardless of whether the saccharin was novel or familiar. The pattern of behavioural deficits obtained cannot be …
Conditioned Taste Aversion And Latent Inhibition Following Extensive Taste Preexposure In Rats With Insular Cortex Lesions, Christopher T. Roman, Jian-You Lin, Steve Reilly
Conditioned Taste Aversion And Latent Inhibition Following Extensive Taste Preexposure In Rats With Insular Cortex Lesions, Christopher T. Roman, Jian-You Lin, Steve Reilly
Christopher Roman
Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar and as a result show a latent inhibition-like retardation of learning. This account anticipates that ICX rats should acquire CTAs at the same slow rate as normal rats that are familiar with the taste stimulus. The present experiment confirmed this hypothesis in a design that compared CTA acquisition in normal …