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Full-Text Articles in Neuroscience and Neurobiology
Schizophrenia- Like Attentional Deficits Following Blockade Of Prefrontal Cortex Gaba(A) Receptors, Tracie A. Paine, Lauren E. Slipp, William A. Carlezon Jr.
Schizophrenia- Like Attentional Deficits Following Blockade Of Prefrontal Cortex Gaba(A) Receptors, Tracie A. Paine, Lauren E. Slipp, William A. Carlezon Jr.
Faculty & Staff Scholarship
Attentional deficits are a core symptom of schizophrenia. Post-mortem analyses of the brains of schizophrenics reveal consistent abnormalities in gamma-aminobutyric acid (GABA) interneurons indicative of reduced cortical GABA transmission, raising the possibility that this pathology contributes to attentional deficits. We examined whether blockade of prefrontal cortex (PFC) GABA(A) receptors with bicuculline (BMI) impairs attention in rats using the 5-choice serial reaction time task (5CSRTT). For comparison, we also examined whether administration of the GABA(A) receptor agonist muscimol (MUS) would improve attention. In parallel, we examined the effects of both manipulations on activity in an open field and on motivation using …
Pavlovian Conditioning Between Cocaine Stimulant Effects And A Discrete Sensory Cue: Implementation Of An Alternating Conditioning Procedure, Jonathan Miller Wachtel
Pavlovian Conditioning Between Cocaine Stimulant Effects And A Discrete Sensory Cue: Implementation Of An Alternating Conditioning Procedure, Jonathan Miller Wachtel
Honors Papers
Cocaine addiction is associated with an extremely high rate of relapse, the resumption of drug taking behavior following a period of abstinence. Relapse may be induced by exposure to drug-associated cues, stress, or drug challenge. Rodent models of addiction investigate reinstatement, the resumption of drug-seeking behavior following a period of abstinence. This study investigated the necessary procedures for establishing Pavlovian conditioning between a discrete sensory cue and cocaine stimulant effects (15.0 mg/kg, IP). Successful conditioning was indicated by cue induced conditioned hyperactivity. In Experiment 1, a simple discrete visual cue failed to be attributed salience. Cocaine-treated rats showed heightened locomotor …