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Full-Text Articles in Neuroscience and Neurobiology
Exercise As A Natural Kappa Opioid Receptor Antagonist To Treat Binge Drinking Withdrawal, Eleanor Wind
Exercise As A Natural Kappa Opioid Receptor Antagonist To Treat Binge Drinking Withdrawal, Eleanor Wind
Honors Theses
Binge drinking is a major concern, especially among college students. Positive results have been demonstrated in clinical trials that utilized exercise to treat alcohol use disorder, but questions remain regarding the type of exercise and how it should be administered across ages and sexes. Studies using animal models have investigated the neurobiological mechanisms of this treatment to improve understanding of how to implement it. One of the mechanisms under investigation is the endogenous opioid system, specifically the kappa opioid receptor (KOR) subtype. Previous research has demonstrated that exercise treatment concurrent with ethanol exposure attenuated an ethanol-induced increase in KOR receptor …
Sex-Specific Effects Of High-Fat And Ketogenic Diet On Inflammatory Responses In The Hippocampus, Shalet James
Sex-Specific Effects Of High-Fat And Ketogenic Diet On Inflammatory Responses In The Hippocampus, Shalet James
Honors Theses
Poor diet and metabolic diseases (obesity, Type 2 diabetes) are associated with increased risk of neurodegenerative and neuropsychiatric disorders, including Alzheimer’s disease, anxiety, and depression. Studies indicate that inflammation in the hippocampus could be one mechanism linking these conditions. Previous findings on inflammation, specifically glial activity in response to a high-fat diet, indicate sex differences in microglial responses in the hippocampus. The ketogenic diet is characterized by a high-fat, low-carbohydrate, and moderate-protein diet. While the ketogenic diet is very high in fat content, it may also possess neuroprotective properties against brain aging and neurodegenerative disorders, as well as boost mood …