Open Access. Powered by Scholars. Published by Universities.®
Neuroscience and Neurobiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Neuroscience and Neurobiology
The Role Of The Periaqueductal Gray In The Modulation Of Pain In Males And Females: Are The Anatomy And Physiology Really That Different?, Dayna R. Loyd, Anne Z. Murphy Phd
The Role Of The Periaqueductal Gray In The Modulation Of Pain In Males And Females: Are The Anatomy And Physiology Really That Different?, Dayna R. Loyd, Anne Z. Murphy Phd
Neuroscience Institute Faculty Publications
Anatomical and physiological studies conducted in the 1960s identified the periaqueductal gray (PAG) and its descending projections to the rostral ventromedial medulla (RVM) and spinal cord dorsal horn, as a primary anatomical pathway mediating opioid-based analgesia. Since these initial studies, the PAG-RVM-spinal cord pathway has been characterized anatomically and physiologically in a wide range of vertebrate species. Remarkably, the majority of these studies were conducted exclusively in males with the implicit assumption that the anatomy and physiology of this circuit were the same in females; however, this is not the case. It is well established that morphine administration produces greater …
Sexually Dimorphic Activation Of The Periaqueductal Gray – Rostral Ventromedial Medullary Circuit During The Development Of Morphine Tolerance In The Rat, Dayna R. Loyd, Michael M. Morgan, Anne Z. Murphy Phd
Sexually Dimorphic Activation Of The Periaqueductal Gray – Rostral Ventromedial Medullary Circuit During The Development Of Morphine Tolerance In The Rat, Dayna R. Loyd, Michael M. Morgan, Anne Z. Murphy Phd
Neuroscience Institute Faculty Publications
Previous studies have shown that tolerance develops to a greater degree in male compared to female rats. The midbrain periaqueductal gray (PAG), and its descending projections to the rostral ventromedial medulla (RVM), provides an essential neural circuit for the antinociceptive effects of opiates and has been implicated in the development of tolerance to morphine. We have previously reported that systemic morphine administration activates a greater proportion of PAG-RVM neurons in male versus female rats; our hypothesis is that if the PAG-RVM pathway is essential for the development of morphine tolerance, then (1) morphine activation of the PAG-RVM pathway should decline …
Morphine Preferentially Activates The Periaqueductal Gray – Rostral Ventromedial Medullary Pathway In The Male Rat: A Potential Mechanism For Sex Differences In Antinociception, Dayna R. Loyd, Michael M. Morgan, Anne Z. Murphy Phd
Morphine Preferentially Activates The Periaqueductal Gray – Rostral Ventromedial Medullary Pathway In The Male Rat: A Potential Mechanism For Sex Differences In Antinociception, Dayna R. Loyd, Michael M. Morgan, Anne Z. Murphy Phd
Neuroscience Institute Faculty Publications
The midbrain periaqueductal gray (PAG), and its descending projections to the rostral ventromedial medulla (RVM), provide an essential neural circuit for opioid-produced antinociception. Recent anatomical studies have reported that the projections from the PAG to the RVM are sexually dimorphic and that systemic administration of morphine significantly suppresses pain-induced activation of the PAG in male but not female rats. Given that morphine antinociception is produced in part by disinhibition of PAG output neurons, it is hypothesized that a differential activation of PAG output neurons mediates the sexually dimorphic actions of morphine. The present study examined systemic morphine-induced activation of PAG-RVM …