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Full-Text Articles in Neuroscience and Neurobiology
Effects Of Apolipoprotein E On Olfactory Nerve Plasticity In Mice, Jody L. Short
Effects Of Apolipoprotein E On Olfactory Nerve Plasticity In Mice, Jody L. Short
Masters Theses
No abstract provided.
Effects Of E2 On Apoe Secretion And Neurite Outgrowth In Cultured Adult Mouse Cortical Neurons, Fei Shen
Effects Of E2 On Apoe Secretion And Neurite Outgrowth In Cultured Adult Mouse Cortical Neurons, Fei Shen
Masters Theses
Estrogen replacement therapy appears to delay the onset of Alzheimer's disease (AD). The mechanism whereby estrogen prevents the pathogenesis of AD is unknown. In the present study, I examined the effects of 17-β-estradiol (E2) on neurite outgrowth from adult mice cortical neurons (AMC) in culture. I found that E2 increases apoE secretion and neurite outgrowth in AMC neurons from wild type mice in a dose dependent fashion. The neurite outgrowth promoting effect of E2 was not observed in AMC neurons derived from age-, sex-, and stain-matched apoE deficient/apoE gene knockout (apoE KO) mice. Furthermore, E2 has isoform specific effects on …
Modulation Of Apolipoprotein E Expression And Glial Activation In Mouse Olfactory Bulb During Estrous Cycle: An Immunohistochemical Study, Matthew Kircher
Modulation Of Apolipoprotein E Expression And Glial Activation In Mouse Olfactory Bulb During Estrous Cycle: An Immunohistochemical Study, Matthew Kircher
Masters Theses
Estrogen (E2) plasma levels fluctuate as a function of estrous cycling in the mouse. Apolipoprotein E (apoE) mRNA has been shown to increase in both hippocampal astrocytes and microglia during proestrus when plasma estrogen levels are high. The current study was designed to evaluate apoE localization and glial activation in mouse olfactory bulb (OB) as a function of the estrous cycle. In the rat OB, estrogen receptor β (ERβ) is present in the glomerular and external plexiform layers, but not the internal plexiform and granule cell layers. Normal female mice 2-3 months old at the start of the study were …
Regional Specific Brain Apoe Modulation By The Estrous Cycle And Exogenous Estrogen, Emily Rosario
Regional Specific Brain Apoe Modulation By The Estrous Cycle And Exogenous Estrogen, Emily Rosario
Masters Theses
Previous studies have demonstrated that 17β-estradiol can modify apolipoprotein E (apoE) expression. I found that apoE protein varied as a function of the estrous cycle and 17β-estradiol (E2) in a region specific manner in the mouse brain. I also found that apoE concentration was lowest on estrus in the hippocampus, cingulate cortex and frontal cortex; apoE concentration was highest on estrus in the olfactory bulb and cerebellum. No changes in apoE were found in the striatum throughout the estrous cycle. Exogenous E2 significantly raised tissue levels in the olfactory bulb and cerebellum, but did not increase apoE in cortical samples …