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Brigham Young University

Interneuron

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Full-Text Articles in Neuroscience and Neurobiology

Novel Pharmacological Target: Characterization Of A3b2 Nachrs Expressed In Xenopus Laevis Oocytes, Doris Jackson, Marcel Hall, J. Kolb, B. Todd Jr., D. Pugh, B. Vance, B. Klienstuber, R. Drecketts, S. N. Sudweeks Apr 2016

Novel Pharmacological Target: Characterization Of A3b2 Nachrs Expressed In Xenopus Laevis Oocytes, Doris Jackson, Marcel Hall, J. Kolb, B. Todd Jr., D. Pugh, B. Vance, B. Klienstuber, R. Drecketts, S. N. Sudweeks

FHSS Mentored Research Conference

We have identified two subtypes of the novel a3b2 nicotinic acetylcholine receptor (nAChR) found within interneurons of the hippocampus. This novel receptor may be a valuable pharmacological target in drug development for disease such as Alzheimer’s disease (AD) which is largely characterized by degeneration of the hippocampus.


Classification Of Neuronal Nicotinic Acetylcholine Receptors In Rat Ca1 Hippocampal Interneuron Subpopulations Defined By Calcium-Binding Protein Mrna Expression, Richard M. Burgon Jul 2006

Classification Of Neuronal Nicotinic Acetylcholine Receptors In Rat Ca1 Hippocampal Interneuron Subpopulations Defined By Calcium-Binding Protein Mrna Expression, Richard M. Burgon

Theses and Dissertations

In this study, the single-cell relative quantitative mRNA expression of three Calcium-binding proteins (CaBPs; calbindin, calretinin, parvalbumin) and eight nicotinic acetylcholine receptor (nAChR) subunits (alpha2-alpha5, alpha7, beta2-beta4) from interneurons from the stratum radiatum or stratum oriens within the CA1 region of rat hippocampi was analyzed using quantitative real time RT-PCR. Eighty-seven percent of the interneurons examined expressed CaBP mRNA. Parvalbumin mRNA was detected in 64%, while calbindin and calretinin expression was detected in 26% and 40% of interneurons, respectively. CaBP expression was not exclusive; the average number of CaBP mRNA detected per interneuron of the 47 interneurons examined for CaBP …