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Palmitoylation And Oxidation Of The Cysteine Rich Region Of Snap-25 And Their Effects On Protein Interactions, Derek Luberli Martinez
Palmitoylation And Oxidation Of The Cysteine Rich Region Of Snap-25 And Their Effects On Protein Interactions, Derek Luberli Martinez
Theses and Dissertations
Neurons depend upon neurotransmitter release through regulated exocytosis to accomplish the immense processing performed within the central nervous system. The SNARE hypothesis points to a family of proteins that are thought to enable the membrane fusion that leads to exocytosis. The secondary structure of SNAP-25 is unique among SNARE proteins in that it has two alpha helical SNARE motifs and a cysteine rich (C85, C88, C90, C92) membrane interacting region but notransmembrane domain. The cysteines may be modified by palmitoylation or oxidation but the role of these modifications in vivo is not well understood. Our goal is to elucidate possible …